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首页> 外文期刊>The European Journal of Neuroscience >Epigenetic regulation of myelination in health and disease
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Epigenetic regulation of myelination in health and disease

机译：健康与疾病中髓鞘术的表观遗传调节

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摘要

Myelin is lipid-rich structure that is necessary to avoid leakage of electric signals and to ensure saltatory impulse conduction along axons. Oligodendrocytes in central nervous system (CNS) and Schwann cells in peripheral nervous system (PNS) are responsible for myelin formation. Axonal demyelination after injury or diseases greatly impairs normal nervous system function. Therefore, understanding how the myelination process is programmed, coordinated, and maintained is crucial for developing therapeutic strategies for remyelination in the nervous system. Epigenetic mechanisms have been recognized as a fundamental contributor in this process. In recent years, histone modification, DNA modification, ATP-dependent chromatin remodeling, and non-coding RNA modulation are very active area of investigation. We will present a conceptual framework that integrates crucial epigenetic mechanisms with the regulation of oligodendrocyte and Schwann cell lineage progression during development and myelin degeneration in pathological conditions. It is anticipated that a refined understanding of the molecular basis of myelination will aid in the development of treatment strategies for debilitating disorders that involve demyelination, such as multiple sclerosis in the CNS and neuropathies in the PNS.
机译：髓鞘是富有的富含脂质的结构，这是避免电信号泄漏的必要条件，并确保沿着轴突的盐脉冲传导。中枢神经系统（CNS）和外周神经系统（PNS）中的氏菌细胞（PNS）中的少突胶质细胞负责髓鞘形成。损伤或疾病后的轴突脱髓鞘大大损害正常神经系统功能。因此，了解如何编程，协调和维持如何进行编程，协调和维持至关重要，以便在神经系统中制定治疗策略。表观遗传机制已被认为是这一过程中的基本贡献者。近年来，组蛋白修饰，DNA改性，ATP依赖性染色质重塑，并且非编码RNA调制是非常有源的调查区域。我们将提出一个概念框架，将关键的表观遗传机制整合在发育和髓鞘变性在病理条件下的调节和施曼细胞谱系进展。预计对髓鞘开采的分子基础的精致了解将有助于发展涉及脱髓鞘的衰弱疾病的治疗策略，例如CNS中的多发性硬化和PNS中神经病。

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