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首页> 外文期刊>The European Journal of Neuroscience >Postural and muscle responses to galvanic vestibular stimulation reveal a vestibular deficit in adolescents with idiopathic scoliosis
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Postural and muscle responses to galvanic vestibular stimulation reveal a vestibular deficit in adolescents with idiopathic scoliosis

机译:对电流前庭刺激的姿势和肌肉反应显示了具有特发性脊柱侧凸的青少年前庭缺陷

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One of the most appealing hypotheses around the aetiopathogenesis of adolescent idiopathic scoliosis attributes the development of the spine deformity to an imbalance in the descending vestibulospinal drive to the muscles resulting in a differential mechanical pull on the spine during the early life stages. In this study, we explored this hypothesis by examining postural and muscle responses to binaural bipolar galvanic vestibular stimulation (GVS) of randomly alternating polarity. Adolescents diagnosed with idiopathic scoliosis (n = 12) and healthy age-matched controls (n = 12) stood quietly with feet together (stance duration 66-102 s), eyes closed and facing forward, while 10 short (2s), transmastoidal, bipolar square wave GVS pulses (0.3-2.0 mA) of randomly alternating polarity were delivered at varying time intervals. Responses depicted in the electromyographic (EMG) activity of bilateral axial and appendicular muscles, vertical reaction forces and segment kinematics were recorded and analysed. Scoliotic patients demonstrated smaller ankle muscle responses and a delayed postural shift to the right relative to controls during anode right/cathode left GVS. When GVS polarity was reversed, patients had a greater soleus short-latency response on the left anodal side, while the rest of the muscle and postural responses were similar between groups. Vestibular stimulation also evoked greater head and upper trunk sway in scoliotic compared with healthy adolescents irrespective of stimulus polarity. Results provide new preliminary evidence for a vestibular imbalance in adolescents with idiopathic scoliosis that is compensated by somatosensory, load-related afferent feedback from the lower limbs during the latter part of the response.
机译:青少年特发性脊柱侧凸的AetoOp病变周围最吸引人的假设之一属性将脊柱畸形的发展归因于在初期寿命期间导致肌肉下降的前颈部驱动中的失衡。在这项研究中,我们通过检查随机交替极性的双耳双极电流前庭刺激(GVS)的姿势和肌肉反应来探讨这一假设。被诊断患有特发性脊柱侧凸(n = 12)和健康年龄匹配的对照(n = 12)的青少年静静地站在一起(姿势持续时间66-102秒),闭着眼睛,朝向前面,而10短(2s),Transcastoidal,双极方波GVS脉冲以不同的时间间隔输送随机交替极性的脉冲(0.3-2.0mA)。记录并分析了双侧轴向和垂直肌肉,垂直反应力和分段运动学的电拍摄(EMG)活性的反应。脊髓灰皮患者呈现较小的踝关节肌响应和相对于阳极右/阴极左侧的对照的延迟姿势转向。当GVS极性逆转时,患者在左侧阳极侧具有更大的SOLEUS短延迟响应,而剩余的肌肉和姿势反应之间是相似的。与健康青少年相比,前庭刺激也唤起了脊髓灰皮中的更大的头部和上层摇摆,而与健康的青少年无关刺激极性。结果为具有特发性脊柱侧凸的青少年的前庭失衡提供了新的初步证据,该脊柱病由躯体传感病症补偿,在响应的后半部分期间从下肢与下肢相关的累围反馈。

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