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首页> 外文期刊>The European Journal of Neuroscience >Using subjective expectations to model the neural underpinnings of proactive inhibition
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Using subjective expectations to model the neural underpinnings of proactive inhibition

机译：利用主观期望来模拟积极抑制的神经内衬

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Proactive inhibition - the anticipation of having to stop a response - relies on objective information contained in cue-related contingencies in the environment, as well as on the subjective interpretation derived from these cues. To date, most studies of brain areas underlying proactive inhibition have exclusively considered the objective predictive value of environmental cues, by varying the probability of stop-signals. However, by only taking into account the effect of different cues on brain activation, the subjective component of how cues affect behavior is ignored. We used a modified stop-signal response task that includes a measurement for subjective expectation, to investigate the effect of this subjective interpretation. After presenting a cue indicating the probability that a stop-signal will occur, subjects were asked whether they expected a stop-signal to occur. Furthermore, response time was used to retrospectively model brain activation related to stop-expectation. We found more activation during the cue period for 50% stop-signal probability, when contrasting with 0%, in the mid and inferior frontal gyrus, inferior parietal lobe and putamen. When contrasting expected vs. unexpected trials, we found modest effects in the mid frontal gyrus, parietal, and occipital areas. With our third contrast, we modeled brain activation during the cue with trial-by-trial variances in response times. This yielded activation in the putamen, inferior parietal lobe, and mid frontal gyrus. Our study is the first to use the behavioral effects of proactive inhibition to identify the underlying brain regions, by employing an unbiased task-design that temporally separates cue and response.
机译：积极抑制 - 预期不得不停止响应 - 依赖于环境中与环境的举例中有关的客观信息，以及来自这些提示的主观解释。迄今为止，通过改变止血信号的可能性，大多数主动抑制的大脑领域的研究都专门考虑了环境提示的客观预测值。然而，只要考虑到不同提示对脑激活的影响，忽略了提示如何影响行为的主观组成部分。我们使用了一个修改的停止信号响应任务，包括用于主观期望的测量，以研究这种主观解释的影响。在提出指示将发生停止信号的概率的提示之后，询问受试者是否预期停止信号。此外，响应时间用于回顾性地模拟与停止期望相关的脑激活。我们在提示期间发现了更多的激活时间为50％的停止信号概率，当与0％对比时，在中间和较差的前转象，下榫叶和腐烂中。当对比预期的与意外试验时，我们在中间转座，顶叶和枕骨中发现了适度的效果。凭借我们的第三次对比，我们在响应时间的试验方案中建模大脑激活。这在腐烂，劣质叶片和中正相中产生了活化。我们的研究是首先使用主动抑制的行为效应来识别潜在的脑区，通过采用无偏见的任务设计，该设计在临时分离提示和反应。

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