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首页> 外文期刊>The European Journal of Neuroscience >Ultrastructure of giant thalamic terminals in the auditory cortex
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Ultrastructure of giant thalamic terminals in the auditory cortex

机译：在听觉皮层中的巨型丘陵终端超微结构

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摘要

The auditory system comprises some very large axonal terminals like the endbulb and calyx of Held and "giant" corticothalamic synapses. Previously, we described a hitherto unknown population of giant thalamocortical boutons arising from the medial division of the medial geniculate body (MGm) in the Mongolian gerbil, which terminate over a wide cortical range but in a columnar manner particularly in the extragranular layers of the auditory cortex. As a first step towards an understanding of their potential functional role, we here describe their ultrastructure combining anterograde tract-tracing with biocytin and electron microscopy. Quantitative ultrastructural analyses revealed that biocytin-labelled MGm boutons reach much larger sizes than other, non-labelled boutons. Also, mitochondria occupy more space within labelled boutons whereas synapses are of similar size. Labelled boutons are very heterogeneous in size but homogeneous with respect to their ultrastructural characteristics, with asymmetric synapses containing clear, round vesicles and targeting dendritic spines. Functionally, the ultrastructure of the MGm terminals indicates that they form excitatory contacts, which may transmit their information in a rapid, powerful and high-fidelity manner onto strategically advantageous compartments of their cortical target cells.
机译：听觉系统包括一些非常大的轴突终端，如封端和持有的Calyx和“巨型”皮质训练突触。以前，我们描述了蒙古菌根中内侧突变体（Mgm）内侧分裂的巨型巨型巨型群体的迄今为止未知的群体，其终止于宽的皮质范围，但特别是柱状方式，特别是在听觉的颗粒层中皮质。作为对其潜在功能作用的理解的第一步，我们在这里描述了它们与生物霉素和电子显微镜的先进的道追踪结合的超微结构。定量超微结构分析显示，生物霉素标记的MGM Butons达到比其他未标记的Bouton更大的尺寸。此外，线粒体在标记的Boutons内占据了更多空间，而突触具有相似的大小。标记的Boutons的尺寸非常异质，但相对于其超微结构特性均匀，含有透明，圆囊和靶向树突刺的不对称突触。在功能上，MGM终端的超微结构表明它们形成兴奋性触点，其可以以快速，强大的和高保真的方式将其信息传送到其皮质靶细胞的战略有利的隔间。

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