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首页> 外文期刊>The European Journal of Neuroscience >Behavioural and neural sequelae of stressor exposure are not modulated by controllability in females
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Behavioural and neural sequelae of stressor exposure are not modulated by controllability in females

机译：应激源暴露的行为和神经后遗症不受雌性的可控性调节

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Abstract The degree of behavioural control that an organism has over a stressor is a potent modulator of the stressor's impact; controllable stressors produce none of the neurochemical and behavioural sequelae that occur if the stressor is uncontrollable. Research demonstrating the importance of control and the neural mechanisms responsible has been conducted almost entirely with male rats. It is unknown if behavioural control is stress blunting in females, and whether or not a similar resilience circuitry is engaged. Female rats were exposed to controllable, yoked uncontrollable or no tailshock. In separate experiments, behavioural (juvenile social exploration, fear and shuttle box escape) and neurochemical (activation of dorsal raphe serotonin and dorsal rapheprojecting prelimbic neurons) outcomes, which are sensitive to the dimension of control in males, were assessed. Despite successful acquisition of the controlling response, behavioural control did not mitigate dorsal raphe serotonergic activation and behavioural outcomes induced by tailshock, as it does in males. Moreover, behavioural control failed to selectively engage prelimbic cells that project to the dorsal raphe as in males. Pharmacological activation of the prelimbic cortex restored the stressbuffering effects of control. Collectively, the data demonstrate stressor controllability phenomena are absent in females and that the protective prelimbic circuitry is present but not engaged. Reduced benefit from coping responses may represent a novel approach for understanding differential sex prevalence in stressrelated psychiatric disorders.
机译：摘要有机体对压力源的行为控制程度是压力源的影响的有效调制器;如果压力源是无法控制的，可控压力源不会产生发生的神经化学和行为后遗症。研究证明控制的重要性和负责的神经机制几乎完全与雄性大鼠完全进行。如果行为控制是雌性的应力钝化，并且是否接合类似的弹性电路。雌性大鼠接触到可控，不受控制或没有尾轴。在单独的实验中，评估行为（少年社会勘探，恐惧和梭子箱逃生）和神经化学（激活背甲羟色胺和背甲哒r.Prébic神经元）的结果，其对男性对照的尺寸敏感的结果。尽管成功收购了控制响应，但行为控制并未减轻尾轴诱导的背甲状腺酮能激活和行为结果，如雄性。此外，行为控制未能选择性地将投射到雄性中的背部拉皮的前列腺细胞。 Prelimbic皮质的药理活化恢复了对照的应力缓解效果。统称，数据证明了女性中不存在的压力源可控性现象，并且保护性前列电路存在但未接合。从应对应答的减少可能代表了一种了解患患者的精神疾病中差异性行为的新方法。

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