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首页> 外文期刊>The British Journal of Nutrition >Effect of garlic powder supplementation on hepatic steatosis, liver enzymes and lipid profile in patients with non-alcoholic fatty liver disease: a double-blind randomised controlled clinical trial
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Effect of garlic powder supplementation on hepatic steatosis, liver enzymes and lipid profile in patients with non-alcoholic fatty liver disease: a double-blind randomised controlled clinical trial

机译：大蒜粉对非酒精性脂肪肝病患者肝硬化，肝脏酶和脂质曲线的影响：双盲随机对照临床试验

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Non-alcoholic fatty liver disease (NAFLD) includes a range of disorders from simple steatosis to non-alcoholic steatohepatitis. There is no proven drug treatment for NAFLD, and diet modification is considered part of the main line of treatment for this disease. The aim of this study was to investigate the efficacy of garlic supplementation in NAFLD patients. The effect of garlic powder supplementation on hepatic steatosis, liver enzymes and lipid profile was investigated in NAFLD patients. Ninety NAFLD patients were randomly assigned to take either a garlic powder supplement or a placebo for 12 weeks. The treatment group received four tablets of garlic daily (each tablet contained 400 mg garlic powder). The control group received four tablets of placebo (each placebo contained 400 mg starch). At the end of the study, hepatic steatosis was significantly reduced in the treatment group compared with the control group (P= 0 center dot 001). In addition, a significant decrease was seen in the serum concentration of alanine transaminase (P< 0 center dot 001), aspartate transaminase (P= 0 center dot 002), gamma-glutamyltransferase (P= 0 center dot 003) as well as total cholesterol (P= 0 center dot 009), TAG (P< 0 center dot 001), HDL-cholesterol (P< 0 center dot 001) and LDL-cholesterol (P= 0 center dot 01) in the treatment group compared with the control group. No significant difference was seen between the two groups in serum concentration of alkaline phosphatase. Overall, garlic powder supplementation improved hepatic features and lipid profile among NAFLD patients.
机译：非酒精性脂肪肝病（NAFLD）包括一系列疾病，从简单的脂肪变性与非酒精性脱脂性炎。对NAFLD没有经过验证的药物治疗，饮食改性被认为是这种疾病的主要治疗方法的一部分。本研究的目的是探讨大蒜补充在NAFLD患者的疗效。在NAFLD患者中研究了大蒜粉补充对肝硬化，肝脏酶和脂质曲线的影响。九十芽蛋白患者随机分配给大蒜粉补充剂或安慰剂12周。治疗组接受了每天四片大蒜（每片含有400毫克大蒜粉）。对照组接受了四片安慰剂（每个安慰剂含有400mg淀粉）。在该研究结束时，与对照组（P = 0中心点001）相比，治疗组中的肝脏脂肪变性显着降低。此外，在丙氨酸转氨酶（P <0中心点001）的血清浓度下，天冬氨酸转氨酶（P = 0中心点002），γ-谷氨酰胺转移酶（P = 0中心点003）以及总共等胆固醇（p = 0中心点009），标签（P <0中心点001），与治疗组中的HDL-胆固醇（P <0中心点001）和LDL-胆固醇（P = 0中心点01）相比控制组。两组在碱性磷酸酶的血清浓度中没有显着差异。总体而言，大蒜粉补充剂在NAFLD患者中改善了肝功能和脂质型材。

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