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首页> 外文期刊>The British Journal of Nutrition >Resistant starch supplementation increases crypt cell proliferative state in the rectal mucosa of older healthy participants
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Resistant starch supplementation increases crypt cell proliferative state in the rectal mucosa of older healthy participants

机译：抗性淀粉补充剂增加了老年健康参与者直肠粘膜中的隐窝细胞增殖状态

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There is strong evidence that foods containing dietary fibre protect against colorectal cancer, resulting at least in part from its anti-proliferative properties. This study aimed to investigate the effects of supplementation with two non-digestible carbohydrates, resistant starch (RS) and poly-dextrose (PD), on crypt cell proliferative state (CCPS) in the macroscopically normal rectal mucosa of healthy individuals. We also investigated relationships between expression of regulators of apoptosis and of the cell cycle on markers of CCPS. Seventy-five healthy participants were supplemented with RS and/or PD or placebo for 50 d in a 2 x 2 factorial design in a randomised, double-blind, placebo-controlled trial (the Dietary Intervention, Stem cells and Colorectal Cancer (DISC) Study). CCPS was assessed, and the expression of regulators of the cell cycle and of apoptosis was measured by quantitative PCR in rectal mucosal biopsies. SCFA concentrations were quantified in faecal samples collected pre- and post-intervention. Supplementation with RS increased the total number of mitotic cells within the crypt by 60 % (P = 0.001) compared with placebo. This effect was limited to older participants (aged >= 50 years). No other differences were observed for the treatments with PD or RS as compared with their respective controls. PD did not influence any of the measured variables. RS, however, increased cell proliferation in the crypts of the macroscopically-normal rectum of older adults. Our findings suggest that the effects of RS on CCPS are not only dose, type of RS and health status-specific but are also influenced by age.
机译：有强有力的证据表明，含有膳食纤维的食物防止结直肠癌，至少部分地从其抗增殖性质中产生。该研究旨在研究补充剂对健康个体的宏观正常直肠粘膜中的两个不可易消化的碳水化合物，抗性淀粉（RS）和多葡聚糖（Pd）的抗性细胞增殖状态（CCP）。我们还研究了CCPS标志物中凋亡和细胞周期的调节剂表达之间的关系。在随机，双盲，安慰剂对照试验（膳食干预，干细胞和结肠直肠癌（光盘）中，在2×2因子设计中补充了七十五名健康参与者的50 d 50 d。学习）。评估CCP，通过定量PCR在直肠粘膜活组织检查中测量细胞周期调节剂和细胞凋亡的表达。在粪便样本中量化了SCFA浓度，在介入和后后培养中定量。与安慰剂相比，用RS补充在rs增加60％（p = 0.001）中的丝分裂细胞总数。这种效果仅限于年龄较大的参与者（年龄> = 50岁）。与其各自的对照相比，对于Pd或Rs的治疗没有观察到其他差异。 PD不影响任何测量变量。然而，Rs在宏观常规直肠直肠的较老年成年人的隐窝中增加了细胞增殖。我们的研究结果表明，RS对CCP的影响不仅是剂量，RS和健康状况的类型特异性，而且也受年龄的影响。

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