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首页> 外文期刊>The Canadian journal of hospital pharmacy. >Cotrimoxazole-lnduced Tremor
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Cotrimoxazole-lnduced Tremor

机译：Cotrimoxazole诱导的震颤

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摘要

Cotrimoxazole (sulfamethoxazole-trimethoprim) is an anti-infective agent infrequently associated with neurotoxicity. However, the potential for this medication to cause new symptoms of central nervous system irritability or alteration should not be overlooked, as illustrated by the following case. A middle-aged patient, weighing 67 kg, was admitted to the intensive care unit (ICU) for respiratory failure.* Cotrimoxazole (1200 mg sulfamethoxazole and 240 mg trimethoprim) IV every 12 h was initiated for treatment of potential Pneumocystisjirovecii pneumonia. The patient had received a deceased-donor renal transplant 12 years before the current admission to overcome end-stage renal impairment due to immunoglobulin A nephro-pathy. The patient had been receiving tacrolimus monotherapy as immunosuppression therapy up to the time of admission. The patient had also been receiving oral cotrimoxazole (800 mg sulfamethoxazole and 160 mg trimethoprim) 3 times a week for prophylaxis before the admission, with concurrent renal function consistent with an estimated glomerular filtration rate of 57 mL/min.
机译：Cotraimoxazole（Sulfamethoxazole-trimethokim）是一种与神经毒性相关的抗感染剂。然而，不应忽视这种药物导致中枢神经系统烦躁或改变的新症状的可能性，如以下情况所示。重量为67千克的中年患者被呼吸到呼吸衰竭的重症监护病房（ICU）。*开始每12小时（1200mg磺胺甲氧唑和240mg Trimethokim）IV，用于治疗潜在的肺肺痘痘肺炎。由于免疫球蛋白，患者在目前的入场前12年前接受了死者肾移植12年来克服终级肾脏损伤。患者已接受Tacrolimus单药治疗作为免疫抑制治疗，其入院时间。患者在入院前一周内也接受口服COTRIMOxazole（800mg磺胺甲氧唑和160mg甲基硫唑和160mg TRIMETHOPHIM）3次预防，并同时肾功能一致，其估计的肾小球过滤速率为57ml / min。

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