...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Area postrema: fetal maturation, tumours, vomiting centre, somatic growth and role in neuromyelitis optica
【24h】

Area postrema: fetal maturation, tumours, vomiting centre, somatic growth and role in neuromyelitis optica

机译：地区postrema：胎儿成熟，肿瘤，呕吐中心，体细胞生长和神经肌炎Optica的作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The area postrema (AP) in the caudal 4th ventricular floor is unique, highly vascular without blood/brain or /CSF barrier. In addition to its function as the vomiting centre, several other important functions are: part of the circumventricular organs for vasomotor and angiotensin II regulation; a role in neuromyelitis optica related to aquaporin-4; contributor to fetal and postnatal somatic growth. Functions are immature at birth.The purpose of this study was to demonstrate AP neuronal/synaptic/glial maturation in normal fetuses and 3 AP tumours. Transverse sections of the caudal 4th ventricle of 18 normal human fetal brains at autopsy, 6 to 40 weeks were examined; also 3 infants 3-18mos; 2 children. A battery of immunocytochemical neuronal and glial markers: MAP2; calretinin; synaptophysin; vimentin; nestin; GFAP; S-100β protein; were applied to paraffin sections. Two children with AP tumours and one with neurocutaneous melanocytosis, all with pernicious vomiting, were studied. In normal fetuses, AP neurons exhibited cytological maturity and well-formed synaptic circuitry by 14wk gestation. Size/volume increase was disproportionately greater than brainstem growth in 2nd and 3rd trimesters and postnatally. Astrocytes co-expressed vimentin/GFAP but glia were best demonstrated by S-100β protein. Ependyma over the AP in fetuses is simple cuboidal, adjacent to pseudostratified columnar of the 4th ventricular floor. Melanocytes infiltrated AP in the toddler with pernicious vomiting; 2 children had primary AP pilocytic astrocytomas. Though AP is cytologically mature by 14wk, growth increases and functions mature into the postnatal months. We recommend that AP neuropathology include synaptophysin and S-100β at autopsy if AP dysfunction suspected.
机译：尾部第四夜间地板的地区Postrema（AP）是独特的，高血管没有血液/大脑或/ CSF屏障。除了作为呕吐中心的功能外，其他几个重要功能是：血管运动器和血管紧张素II调控的一部分绕道器官;与Aquaporin-4相关的神经髓炎Optica中的作用;胎儿和后躯体生长的贡献者。在出生时功能不成熟。本研究的目的是在正常胎儿和3个AP肿瘤中证明AP神经元/突触/胶质成熟。检查尸检18例正常人体胎儿大脑的横截面，检查6至40周;还有3个婴儿3-18MoS; 2个孩子。免疫细胞化学神经元和胶质标记的电池：MAP2; Calretinin; Synaptophysin; vimentin;依偎; GFAP; S-100β蛋白质;被应用于石蜡切片。研究了两个患有AP肿瘤的患儿和具有神经皮肤细胞症的患儿，所有患有可怕的呕吐物。在正常胎儿中，AP神经元表现出细胞学成熟度和良好的突触电路通过14WK妊娠。大小/体积增加不成比例地大于第二和第3次和第3个中的脑干增长。星形胶质细胞共同表达Vimentin / GFAP，但通过S-100β蛋白最佳地证明了Glia。在胎儿上的AP上的ENENCYMA是简单的立方体，与第4间心室地板的假验证柱状相邻。 Melanocytes渗透在幼儿的渗透的AP，有恶意呕吐; 2名儿童患有初级AP pilocytic星形细胞瘤。虽然AP在14WK的细胞学上成熟，但增长和功能成熟到后几个月。我们建议AP神经病理学包括如果AP功能障碍，则在尸检处包括突触蛋白和S-100β。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号