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P.036 Stroke in people with Down Syndrome: a retrospective study

机译:P.036患有唐氏综合症的人的中风:回顾性研究

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Background: There are only few studies approaching the prevalence and cause of stroke in children and adults with Down Syndrome (DS). Methods: We did a retrospective study of our cohort of 4962 patients of Jerome Lejeune Institute since 2007. We collected age of stroke, clinical presentation, cause (TOAST classification), treatment and clinical course. Results: We identified 20 patients from 6 to 56 years old .In all cases, it was a stroke of ischemic origin.: 8 children with a prevalence of 0.33%. 4 had a cardio-embolic origin, 3 secondary to Moya-Moya syndrome and one of undetermined origin. 12 adults (21 to 52 years old) with a prevalence of 0.46%.The majority of the causes of these ischemic strokes are indeterminate (9 of 12), Conclusions: We found a low prevalence and an ischemic cause in all cases of stroke, which differs from the general population. For pediatric stroke, the causes are expected thromboembolic in a context of heart disease most often or secondary to a Moya-Moya syndrome. For adult strokes, the average age is younger than that in the general population and the cause is indeterminate in most cases. We must better explore our patients to identify the risk factors in DS population.
机译:背景:患有唐氏综合征(DS)的儿童和成人中风的患病率甚至几乎没有少数研究。方法:自2007年以来,我们对我们的杰罗姆·梁鸡岛研究所的4962名患者的队列进行了回顾性研究。我们收集了中风,临床介绍,原因(吐司分类),治疗和临床课程。结果:我们确定了20名患者6至56岁。在所有情况下,它是缺血起源的行程:8名患病率为0.33%。 4具有有心栓塞来源,3继发于MOYA-MOYA综合征,其中一个未定例的起源。 12名成人(21至52岁)的患病率为0.46%。这些缺血性卒中的大部分原因是不确定的(12个),结论:我们发现所有卒中病例中的患病率低和缺血性原因,这与一般人群不同。对于儿科中风,导致预期在心脏病的背景下最常见或继发于Moya-Moya综合征的血栓栓塞。对于成人抚摸,平均年龄比一般人群更年轻,在大多数情况下,原因是不确定的。我们必须更好地探索患者,以确定DS人口中的危险因素。

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