• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >The Use of Milrinone in Patients with Delayed Cerebral Ischemia Following Subarachnoid Hemorrhage: A Systematic Review
【24h】

The Use of Milrinone in Patients with Delayed Cerebral Ischemia Following Subarachnoid Hemorrhage: A Systematic Review

机译：蛛网膜下腔出血后延迟脑缺血患者使用MilRinone：系统评价

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: The purpose of this article is to provide a systematic review of the evidence supporting the use of milrinone for the management of delayed cerebral ischemia (DCI) following subarachnoid hemorrhage (SAH). Design: Primary outcomes were functional neurological status and the incidence of cerebral infarction. Search strategies adapted to the different databases were developed by a professional librarian. Medline, EMBASE, the Cochrane Library database, Web of Science, SCOPUS, BIOSIS, Global Health, Health Star, Open SIGLE, Google Scholar and the New York Academy of Medicine Gray Literature were searched as well as clinical trials databases and the proceedings of several scientific meetings. Quality of the evidence for these outcomes across studies was adjudicated using the GRADE Working Group criteria. Results: The search resulted in 284 citations after elimination of duplicates. Of those 9 conference proceedings and 15 studies met inclusion criteria and consisted of case reports, case series and two comparative studies: one non-randomized study with physiological outcomes only and a case series with historical controls. There was considerable variation in dosing and in co-interventions and no case control or randomized controlled studies were found. Conclusion: There is currently only very low quality evidence to support the use of milrinone to improve important outcomes in patients with delayed cerebral ischemia secondary to subarachnoid hemorrhage. Further research is needed to clarify the value and risks of this medication in patients with SAH.
机译：目的：本文的目的是提供对支持使用MilRinone进行延迟脑缺血（DCI）的证据进行系统审查，蛛网膜下腔出血（SAH）。设计：主要结果是功能性神经状态和脑梗塞的发生率。适用于不同数据库的搜索策略是由专业图书管理员开发的。 Medline，Embase，Cochrane Library数据库，科学网，Scopus，Biosis，全球卫生，健康明星，开放的Sigle，Google Scholar和纽约医学院灰色文学以及临床试验数据库和几个诉讼程序科学会议。使用年级工作组标准裁定跨研究的这些结果的证据质量。结果：在消除重复后，搜索导致了284个引文。在这项9个会议上和15项研究中符合纳入标准，包括案例报告，案例系列和两项比较研究：仅具有生理结果的一个非随机性研究以及具有历史控制的案例系列。给药和共同干预有相当大的变异，没有发现任何案例控制或随机对照研究。结论：目前只有非常低的质量证据来支持利用Milrinone，改善患有次脑缺血患者的重要成果。需要进一步研究，以澄清SAH患者的这种药物的价值和风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号