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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >P.092 The effect of the timing of surgery on outcomes for incidental low-grade gliomas: a systematic review
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P.092 The effect of the timing of surgery on outcomes for incidental low-grade gliomas: a systematic review

机译：P.092手术时序对偶然低级GLIMAS的结果：系统审查

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Background: Although previous research has suggested that patients with incidentally discovered low-grade gliomas (iLGG) who undergo surgery prior to the appearance of symptoms have improved outcomes compared to those who are symptomatic, an ideal approach to managing iLGG is not well-established. The purpose of this systematic review is to identify all cases of iLGG in the literature and characterize the effect of the timing of surgery on survival. Methods: We searched EMBASE, MEDLINE, and PubMed for articles related to iLGG. After duplicates were removed, the articles were then screened based on strict inclusion and exclusion criteria. Results: We retrieved 24/1377 unique articles with a total of 175 patients who underwent surgery for iLGG prior to symptoms appearing. The average age was 29.1yrs (range 1-62) and the mean follow-up period was 56 months (range 1-234months). Unfortunately, only 6/24 articles reported progression-free survival (average 32.4months) and only 1/24 reported 10-year survival. Conclusions: The articles we identified favored an early intervention for iLGG, however, there was a considerable lack of long-term follow-up and survival data to justify such a claim. Further studies need to be performed with adequate follow-up data in order to determine the optimal timing of surgical intervention for these patients.
机译：背景：虽然以前的研究表明，偶然发现患者在症状外出现之前偶然发现手术的低级胶质瘤（ILGG），但与症状的人相比具有改善的结果，其管理ILGG的理想方法并不完整。该系统审查的目的是识别文献中的所有ILGG病例，并表征手术时机对生存时的效果。方法：搜索Embase，Medline和PubMed用于与ILGG相关的文章。除去重复后，然后基于严格的包容性和排除标准筛选制品。结果：我们检索了24/1377件独特的文章，共有175名患者在出现症状之前接受ILGG的手术。平均年龄为29.1岁（范围1-62），平均随访期为56个月（范围1-234个月）。不幸的是，只有6/24条文章报告了无进展生存（平均32.4个月），只有1/24报告10年生存。结论：我们发现的文章赞成对ILGG的早期干预，然而，有可能缺乏长期随访和生存数据，以证明这种索赔。需要使用足够的后续数据进行进一步的研究，以确定这些患者的外科手术干预的最佳时间。

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