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首页> 外文期刊>The international journal of developmental biology >Trunk neural crest cells: formation, migration and beyond
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Trunk neural crest cells: formation, migration and beyond

机译：树干神经嵴细胞：形成，迁移和超越

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摘要

Neural crest cells (NCCs) are a multipotent, migratory cell population that generates an astonishingly diverse array of cell types during vertebrate development. The trunk neural crest has long been considered of particular significance. First, it has been held that the trunk neural crest has a morphogenetic role, acting to coordinate the development of the peripheral nervous system, secretory cells of the endocrine system and pigment cells of the skin. Second, the trunk neural crest additionally has skeletal potential. However, it has been demonstrated that a key role of the trunk neural crest streams is to organize the innervation of the intestine. Although trunk NCCs have a limited capacity for self-renewal, sometimes they become neural-crest-derived tumor cells and reveal the fact that that NCCs and tumor cells share the same molecular machinery. In this review we describe the routes taken by trunk NCCs and consider the signals and cues that pattern these trajectories. We also discuss recent advances in the characterization of the properties of trunk NCCs for various model organisms in order to highlight common themes. Finally, looking to the future, we discuss the need to translate the wealth of data from animal studies to the clinical area in order to develop treatments for neural crest-related human diseases.
机译：神经嵴细胞（NCCs）是一种多能的迁移细胞群，在脊椎动物发育过程中产生惊人的多种细胞类型。躯干神经嵴长期以来一直被认为是特别的意义。首先，已经认为，躯干神经嵴具有形态发生的作用，作用以协调外周神经系统的发展，内分泌系统的分泌细胞和皮肤的颜料细胞。其次，躯干神经嵴另外具有骨骼潜力。然而，已经证明了树干神经嵴流的关键作用是组织肠道的支配。虽然树干NCC具有有限的自我更新能力，但有时它们成为神经嵴衍生的肿瘤细胞，并揭示了NCCs和肿瘤细胞患者共享相同的分子机制。在本报告中，我们描述了Trunk NCCS拍摄的路线，并考虑模式和提示这些轨迹的信号和提示。我们还讨论了最近在各种模型生物体中突出NCCS性质的表征的进展，以突出共同主题。最后，展望未来，我们讨论了将动物研究的大量数据转化为临床区域，以便为神经嵴相关的人类疾病进行治疗。

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