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Insights into neural crest development from studies of avian embryos

机译:从禽胚胎研究中洞察神经嵴发展

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The neural crest is a multipotent and highly migratory cell type that contributes to many of the defining features of vertebrates, including the skeleton of the head and most of the peripheral nervous system. 150 years after the discovery of the neural crest, avian embryos remain one of the most important model organisms for studying neural crest development. In this review, we describe aspects of neural crest induction, migration and axial level differences, highlighting what is known about the underlying gene regulatory mechanisms. Past and emerging technologies continue to improve the resolution with which we can examine important questions of neural crest development, with modern avian molecular embryology continuing to make important contributions.
机译:神经嵴是一种多能和高度迁移的细胞类型,有助于脊椎动物的许多定义特征,包括头部和大部分外周神经系统的骨骼。 在发现神经嵴的情况下150年,禽胚胎仍然是研究神经嵴发展的最重要的模型生物之一。 在本文中,我们描述了神经嵴诱导,迁移和轴向差异的方面,突出了关于潜在基因调节机制所知的内容。 过去和新兴技术继续提高我们可以研究神经嵴发展的重要问题的决议,现代禽分子胚胎继续提出重要贡献。

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