New semisynthetic teicoplanin derivatives have comparable in vitro activity to that of oritavancin against clinical isolates of VRE

Szucs Zsolt; Ostorhazi Eszter; Kicsak Mate; Nagy Lajos; Borbas Aniko; Herczegh Pal

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New semisynthetic teicoplanin derivatives have comparable in vitro activity to that of oritavancin against clinical isolates of VRE

机译：新的半合成蛋白衍生物与oritavancin对VRE的临床分离株的体外活性相当

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Ten analogues of a teicoplanin pseudoaglycon derivative have been synthesized with the aim of optimizing the in vitro activity of the compound against VanA type vancomycin resistant enterococci (VRE) isolated from hospitalized patients. Teicoplanin, vancomycin, and oritavancin were used as reference antibiotics for the antibacterial evaluations. One of the new derivatives exhibited far superior activity than the original compound. The in vitro MICs measured were comparable to that of oritavancin against the investigated VRE strains.

机译：已经合成了Teicoplanin伪晶型衍生物的十种类似物，目的是优化对来自住院患者分离的Vana型万古霉素抗性肠球菌（VRE）的化合物的体外活性。 Teicoplanin，万古霉素和oritavancin用作抗菌评估的参考抗生素。其中一种新的衍生物表现出比原始化合物更优异的活动。测量的体外麦克风与对研究的VRE菌株的Oritavancin的体外麦克风相当。

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来源
《The Journal of Antibiotics: An International Journal》 |2019年第7期|共11页
作者
Szucs Zsolt; Ostorhazi Eszter; Kicsak Mate; Nagy Lajos; Borbas Aniko; Herczegh Pal;
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Univ Debrecen Dept Pharmaceut Chem Egyet Ter 1 H-4032 Debrecen Hungary;

Semmelweis Univ Dept Med Microbiol Nagyvarad Ter 4 H-1089 Budapest Hungary;

Univ Debrecen Dept Pharmaceut Chem Egyet Ter 1 H-4032 Debrecen Hungary;

Univ Debrecen Dept Appl Chem Egyet Ter 1 H-4032 Debrecen Hungary;

Univ Debrecen Dept Pharmaceut Chem Egyet Ter 1 H-4032 Debrecen Hungary;

Univ Debrecen Dept Pharmaceut Chem Egyet Ter 1 H-4032 Debrecen Hungary;

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正文语种 eng
中图分类药学;
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1. New semisynthetic teicoplanin derivatives have comparable in vitro activity to that of oritavancin against clinical isolates of VRE [J] . Szucs Zsolt, Ostorhazi Eszter, Kicsak Mate, The Journal of Antibiotics: An International Journal . 2019,第7期

机译：新的半合成蛋白衍生物与oritavancin对VRE的临床分离株的体外活性相当
2. Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. [J] . Arhin FF, Draghi DC, Pillar CM Antimicrobial agents and chemotherapy. . 2009,第11期

机译：奥利万星对近期革兰氏阳性临床分离株的体外活性比较。
3. In vitro activity of a new semisynthetic echinocandin, micafungin, against clinical isolates of Candida species isolated in Tenri Hospital [J] . Komatsu M, Aihara M, Shimakawa K, The Japanese journal of antibiotics . 2003,第6期

机译：新的半合成棘皮菌素米卡芬净对天理医院分离出的念珠菌的临床分离株的体外活性
4. In vitro activity of cathelicidin peptides against fungal clinical isolates [C] . Renato Gennaro, Monica Benincasa, Donatella Nobili, European Peptide Symposium . 2002

机译：肝癌肽对真菌临床分离株的体外活性
5. In vitro Evaluation of Virulence Characteristics of Lipopolysaccharide from Two Different Clinical Isolates of Tannerella forsythia [D] . Albanyan, Hajar 2019

机译：连翘坦索氏菌两种不同临床分离物脂多糖毒力特性的体外评价
6. Antimicrobial activity of MDL 62873 a semisynthetic derivative of teicoplanin in vitro and in experimental infections. [O] . M Berti, G Candiani, M Borgonovi, 1992

机译：MDL 62873（替考拉宁的半合成衍生物）在体外和实验感染中的抗菌活性。
7. Antimicrobial activity of MDL 62,873, a semisynthetic derivative of teicoplanin, in vitro and in experimental infections. [O] . Berti, M, Candiani, G, Borgonovi, M, 1992

机译：MDL 62,873（替考拉宁的半合成衍生物）在体外和实验感染中的抗菌活性。

New semisynthetic teicoplanin derivatives have comparable in vitro activity to that of oritavancin against clinical isolates of VRE

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