Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities

Song Yongxiang; Yang Jiafan; Yu Jianchen; Li Jie; Yuan Jie; Wong Nai-Kei; Ju Jianhua

首页> 外文期刊>The Journal of Antibiotics: An International Journal >Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities

【24h】

Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities

机译：来自深海衍生的链霉菌SP的氯化双吲哚生物碱。 SCSIO 11791具有抗菌和细胞毒性活动

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Two new chlorinated bis-indole alkaloids, dionemycin (1) and 6-OMe-7 ',7 ''-dichorochromopyrrolic acid (2), along with seven known analogs 3-9, were isolated from the deep-sea derived Streptomyces sp. SCSIO 11791. Their structures were elucidated by extensive HRESIMS, and 1D and 2D NMR data analysis. In vitro antibacterial and cytotoxic assays revealed that, compound 1, shows anti-staphylococcal activity with an MIC range of 1-2 mu g/mL against six clinic strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated from human and pig. Additionally, compound 1 displayed cytotoxic activity against human cancer cell lines NCI-H460, MDA-MB-231, HCT-116, HepG2, and noncancerous MCF10A with an IC50 range of 3.1-11.2 mu M. Analysis of the structure-activity relationship reveals that the chlorine atom at C-6 '' could be pivotal for conferring their bioactivities, thus providing hints on chemical modifications on bis-indole alkaloid scaffold in drug design.

机译：两种新的氯化双吲哚生物碱，二硫嘧啶（1）和6-OME-7'，7' - 二巯基吡咯酸（2）以及七种已知的类似物3-9，从深海衍生的链霉菌SP中分离出来。 SCSIO 11791。通过广泛的Hresims和1D和2D NMR数据分析阐明了它们的结构。体外抗菌和细胞毒性测定显示，化合物1显示抗葡葡萄球菌活性，其麦克风范围为1-2μg/ ml，其六个临床型甲氧西林耐金黄色葡萄球菌（MRSA）中分离出来的人和猪。另外，化合物1针对人癌细胞系NCI-H460，MDA-MB-231，HCT-116，HepG2和非癌变的MCF10A显示了细胞毒性活性，IC50范围为3.1-11.2μm。结构 - 活动关系的分析显示 C-6''的氯原子可以是赋予其生物活性的枢转，从而为药物设计中的双吲哚生物碱支架上的化学修饰提供了暗示。

著录项

来源
《The Journal of Antibiotics: An International Journal》 |2020年第8期|共6页
作者
Song Yongxiang; Yang Jiafan; Yu Jianchen; Li Jie; Yuan Jie; Wong Nai-Kei; Ju Jianhua;
展开▼
作者单位

Chinese Acad Sci RNAM Ctr Marine Microbiol South China Sea Inst Oceanol CAS Key Lab Trop Marine;

Chinese Acad Sci RNAM Ctr Marine Microbiol South China Sea Inst Oceanol CAS Key Lab Trop Marine;

Sun Yat Sen Univ Key Lab Trop Dis Control Minist Educ Guangzhou 510080 Peoples R China;

Chinese Acad Sci RNAM Ctr Marine Microbiol South China Sea Inst Oceanol CAS Key Lab Trop Marine;

Sun Yat Sen Univ Key Lab Trop Dis Control Minist Educ Guangzhou 510080 Peoples R China;

Southern Univ Sci &

Technol Hosp 2 Peoples Hosp Shenzhen 3 Natl Clin Res Ctr Infect Dis;

Chinese Acad Sci RNAM Ctr Marine Microbiol South China Sea Inst Oceanol CAS Key Lab Trop Marine;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词

相似文献

外文文献
中文文献
专利

1. Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities [J] . Song Yongxiang, Yang Jiafan, Yu Jianchen, The Journal of Antibiotics: An International Journal . 2020,第8期

机译：来自深海衍生的链霉菌SP的氯化双吲哚生物碱。 SCSIO 11791具有抗菌和细胞毒性活动
2. Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399 [J] . Cong Ziwen, Huang Xiaolong, Liu Yunhao, The Journal of Antibiotics: An International Journal . 2019,第1期

机译：来自海洋衍生的链霉菌SP的细胞毒性蒽环素和抗菌脂胺类似物。 SCSIO 41399.
3. Antibacterial and Cytotoxic New Napyradiomycins from the Marine-Derived Streptomyces sp. SCSIO 10428 [J] . Changsheng Zhang, Haibo Zhang, Jie Li, Marine Drugs . 2013,第6期

机译：海洋衍生链霉菌属细菌的抗菌和细胞毒性新吡虫啉。 SCSIO 10428
4. Potential Antibacterial Activity of Endophytic Fungi Penicillium sp. and Trichoderma sp. Derived From Mangrove Ceriops Tagal (Perr.) C.B.Robb and Bruguiera sp. [C] . Yuli Haryani, Rahmiwati Hilma, Noviza Delfira, Universitas Riau International Conference on Science and Environment . 2020

机译：内生真菌青霉素SP的潜在抗菌活性。和trichoderma sp。来自红树林Ceriops Tagal（Perr。）C.B.Robb和Bruguiera Sp。
5. Studies on nitrogen-containing secondary metabolites from terrestrial and marine origin: Part I. Enzymatic epoxidation of 2,5-dihydroxyacetanilide in Streptomyces sp. Part II. Synthesis of marine sponge alkaloids: Slagenins, axinohydantoins, and studies towards the pyrrolopiperazine system in the agelastatin core. [D] . Barrios Sosa, Ana Carolina. 2002

机译：陆生和海洋来源的含氮次生代谢产物的研究：第一部分。链霉菌属中2,5-二羟基乙酰苯胺的酶促环氧化。第二部分海洋海绵生物碱的合成：Slagenins，Axinohydantoins，以及在astlastatin核心中对吡咯烷哌嗪系统的研究。
6. Cytotoxic and Antibacterial Angucycline- and Prodigiosin- Analogues from the Deep-Sea Derived Streptomyces sp. SCSIO 11594 [O] . Yongxiang Song, Guangfu Liu, Jie Li, 2015

机译：来自深海衍生的链霉菌sp。的细胞毒性和抗菌素金霉素和Prodigiosin类似物。 SCSIO 11594
7. Cytotoxic and Antibacterial Angucycline- and Prodigiosin- Analogues from the Deep-Sea Derived Streptomyces sp. SCSIO 11594 [O] . Yongxiang Song, Guangfu Liu, Jie Li, 2015

机译：来自Deep-sea Derived streptomyces sp。的细胞毒性和抗菌angucycline-和prodigiosin-类似物。 sCsIO 11594

Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities

摘要

著录项

相似文献

相关主题

期刊订阅