Nocardamin glucuronide, a new member of the ferrioxamine siderophores isolated from the ascamycin-producing strain Streptomyces sp. 80H647

Lopez Julius Adam V; Nogawa Toshihiko; Futamura Yushi; Shimizu Takeshi; Osada Hiroyuki

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Nocardamin glucuronide, a new member of the ferrioxamine siderophores isolated from the ascamycin-producing strain Streptomyces sp. 80H647

机译：Nocardamin葡萄糖醛酸，从亚胱内霉素的菌株中分离出的亚霉素施霉菌的新成员Streptomyces sp。 80H647

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A new siderophore glucuronide, nocardamin glucuronide (1), was isolated together with nocardamin (2) by applying the one strain-many compounds (OSMAC) approach to the ascamycin-producing strain, Streptomyces sp. 80H647, and performing multivariate analysis using mass spectral data. Structure elucidation was accomplished by a combination of NMR and MS analyses. The absolute configuration of the glucuronic acid moiety was found to be beta-D-GlcA by hydrolysis using beta-glucuronidase, subsequent derivatization of the hydrolysate, and comparison with standards. The siderophore activity of 1 was evaluated through the chrome azurol S assay and was comparable to that of 2 and deferoxamine (IC50 13.4, 9.5, and 6.3 mu M, respectively). Nocardamin glucuronide (1) is the first example of a siderophore glucuronide.

机译：通过将一种菌株 - 许多化合物（OSMAC）方法施加到亚胱霉素的菌株，Streptomyces Sp，与Nocardamin（2）一起分离出一种新的葡萄押葡萄糖醛酸酯（2）。 80H647，并使用质谱数据进行多变量分析。结构阐明是通过NMR和MS分析的组合完成的。发现葡糖醛酸部分的绝对构型通过使用β-葡糖醛酸酶，随后的水解产物衍生化，以及与标准的衍生化进行水解。通过铬氧脲S测定法评价1的施工细胞活性，与2和Deferoxamine（IC5013.4,9.5和6.3μm）的相当相当。 Nocardamin葡萄糖醛酸葡萄糖（1）是葡萄糖醛糖苷的第一个例子。

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《The Journal of Antibiotics: An International Journal》 |2019年第12期|共5页
作者
Lopez Julius Adam V; Nogawa Toshihiko; Futamura Yushi; Shimizu Takeshi; Osada Hiroyuki;
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RIKEN Ctr Sustainable Resource Sci Chem Biol Res Grp 2-1 Hirosawa Wako Saitama 3510198 Japan;

RIKEN Ctr Sustainable Resource Sci Chem Biol Res Grp 2-1 Hirosawa Wako Saitama 3510198 Japan;

RIKEN Ctr Sustainable Resource Sci Chem Biol Res Grp 2-1 Hirosawa Wako Saitama 3510198 Japan;

RIKEN Ctr Sustainable Resource Sci Chem Biol Res Grp 2-1 Hirosawa Wako Saitama 3510198 Japan;

RIKEN Ctr Sustainable Resource Sci Chem Biol Res Grp 2-1 Hirosawa Wako Saitama 3510198 Japan;

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中图分类药学;
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1. Nocardamin glucuronide, a new member of the ferrioxamine siderophores isolated from the ascamycin-producing strain Streptomyces sp. 80H647 [J] . Lopez Julius Adam V, Nogawa Toshihiko, Futamura Yushi, The Journal of Antibiotics: An International Journal . 2019,第12期

机译：Nocardamin葡萄糖醛酸，从亚胱内霉素的菌株中分离出的亚霉素施霉菌的新成员Streptomyces sp。 80H647
2. Pseudomonas fluorescens Pirates both Ferrioxamine and Ferricoelichelin Siderophores from Streptomyces ambofaciens [J] . Justine Galet, Aurélie Deveau, Laurence H?tel, Applied and Environmental Microbiology . 2015,第9期

机译：荧光假单胞菌从竹链霉菌中盗版铁氧胺和铁弹性螯合铁载体
3. Pseudomonas fluorescens Pirates both Ferrioxamine and Ferricoelichelin Siderophores from Streptomyces ambofaciens [J] . Justine Galet, Aurélie Deveau, Laurence H?tel, Applied Microbiology . 2015,第9期

机译：荧光假单胞菌从竹链霉菌中盗版铁氧胺和铁弹性螯合铁载体
4. A Pseudomonas sp. isolated from calcareous soil can tolerate stress by phenolic compounds exuded by red clover (Trifolium pratense L.) roots and secrete siderophores [C] . X.H. Yu, C.W. Jin, J.L. Yang, International Plant Nutrition Colloquium . 2005

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机译：新型细菌的表征和地球化学，Gen。Nov.，Sp。十一月，Anaeropaleothermus hephaestusseraphensis菌株Siuc-3，离地下3.2公里，位于南非Driefontein金矿
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Nocardamin glucuronide, a new member of the ferrioxamine siderophores isolated from the ascamycin-producing strain Streptomyces sp. 80H647

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