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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Augmented antibacterial activity of ampicillin with silver nanoparticles against methicillin-resistant Staphylococcus aureus (MRSA)
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Augmented antibacterial activity of ampicillin with silver nanoparticles against methicillin-resistant Staphylococcus aureus (MRSA)

机译：用银纳米胺对抗甲氧西林金黄色葡萄球菌（MRSA）的增强蛋白酶抗菌活性

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At present, including failed attempts, it takes about 15 years and costs totaling up to $2.6 billion to take a promising new compound from laboratory to the market. Increasing drug resistance among microbial pathogens has led to a growing interest in exploring novel methods to enhance the efficacy of existing drugs. Combination therapies involving two or more known antimicrobial methods, particularly those involving nanoparticles for combating the clinical problems associated with antibiotic resistance, have been garnering interest. In the current study, we determined whether a combination therapy involving silver nanoparticles, which are known for their antimicrobial activity, and the widely used antibiotic ampicillin can be effective against methicillin-resistant Staphylococcus aureus (MRSA). In the presence of sub-lethal dose of silver nanoparticles, ampicillin was found to be effective against MRSA. Indeed, the results show that silver nanoparticles and ampicillin act synergistically, with the effect being more pronounced when a lower concentration of ampicillin is present. When present at a higher concentration, ampicillin coats the silver nanoparticle, preventing the direct interaction of nanoparticles and bacteria. This study discusses the possible applications of combination antimicrobial therapies involving silver nanoparticles for therapeutic treatments.
机译：目前，包括失败的尝试，大约需要15年，总额高达26亿美元，从实验室到市场上有希望的新化合物。增加微生物病原体之间的耐药性导致探索新方法以增强现有药物的功效的兴趣日益增长。涉及两种或更多种已知的抗微生物方法的组合疗法，特别是涉及纳米颗粒用于打击与抗生素抗性相关的临床问题的组合疗法，这一直是利益的兴趣。在目前的研究中，我们确定了涉及银纳米颗粒的组合治疗，这些组合治疗是针对它们的抗微生物活性而已知的，并且广泛使用的抗生素氨苄青霉素可以对甲氧西林金黄色葡萄球菌（MRSA）有效。在亚致死剂量的银纳米颗粒存在下，发现氨苄青霉素对MRSA有效。实际上，结果表明，银纳米粒子和氨苄青霉素协同作用，当存在较低浓度的氨苄青霉素时，效果更加明显。当以更高的浓度存在时，氨苄青霉素涂上银纳米粒子，防止纳米颗粒和细菌的直接相互作用。本研究讨论了涉及银纳米粒子用于治疗治疗的组合抗菌疗法的可能应用。

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