• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Antibiotics: An International Journal >Two novel quinomycins discovered by UPLC-MS from Stretomyces sp. HCCB11876
【24h】

Two novel quinomycins discovered by UPLC-MS from Stretomyces sp. HCCB11876

机译：来自Stretomyces SP的UPLC-MS发现的两种新醋霉素。 HCCB11876.

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Two novel quinomycins I (1) and J (3) were discovered by UPLC-MS, then the two novel compounds and five known quinomycins A(2), B(4), E(5), C(6) and monosulfoxide quinomycin (7) were isolated from the culture broth of Streptomyces sp. HCCB11876. The structures of these compounds were elucidated through MS and NMR spectroscopic analysis. Compounds 1-7 showed significant antibacterial and cytotoxic activities. The structure-activity relationship indicated that sulfoxide group in N-methylcysteine of quinomycins (1, 3 and 7) would significantly decrease the antibacterial and cytotoxic activities. Moreover, the antibacterial and cytotoxic activities were decreased with the increase of carbon chain in amino-acid residues.
机译：通过UPLC-MS发现两种新型喹硫菌素I（1）和J（3），然后是两种新化合物和五种已知的醋序列A（2），B（4），E（5），C（6）和二氧砜醋霉素 （7）从Streptomyces sp的培养液中分离出来。 HCCB11876。 通过MS和NMR光谱分析阐明这些化合物的结构。 化合物1-7显示出显着的抗菌和细胞毒性活性。 结构 - 活性关系表明喹甲蛋白（1,3和7）的N-甲基半胱氨酸中的亚砜基将显着降低抗菌和细胞毒性活性。 此外，随着氨基酸残基的碳链的增加，抗菌和细胞毒性活性降低。

著录项

  • 来源
  • 作者

    Yang Zhijun; Shao Lei; Wang Meixia; Rao Min; Ge Mei; Xu Yixin;

  • 作者单位

    Shanghai Univ Medine &

    Hlth Sci Sch Pharm Shanghai Peoples R China;

    Shanghai Univ Medine &

    Hlth Sci Sch Pharm Shanghai Peoples R China;

    Shanghai Normal Univ Shanghai Peoples R China;

    Shanghai Laiyi Ctr Biopharmaceut R&

    D Shanghai Peoples R China;

    Shanghai Laiyi Ctr Biopharmaceut R&

    D Shanghai Peoples R China;

    Shanghai Univ Medine &

    Hlth Sci Sch Pharm Shanghai Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号