Mechanism of action of nucleoside antibacterial natural product antibiotics

Bugg Timothy D. H.; Kerr Rachel V

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Mechanism of action of nucleoside antibacterial natural product antibiotics

机译：核苷抗菌天然产物抗生素的作用机制

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This article reviews the structures and biological activities of several classes of uridine-containing nucleoside antibiotics (tunicamycins, mureidomycins/pacidamycins/sansanmycins, liposidomycins/caprazamycins, muraymycins, capuramycins) that target translocase MraY on the peptidoglycan biosynthetic pathway. In particular, recent advances in structure-function studies, and recent X-ray crystal structures of translocase MraY complexed with muraymycin D2 and tunicamycin are described. The inhibition of other phospho-nucleotide transferase enzymes related to MraY by nucleoside antibiotics and analogues is also reviewed.

机译：本文审查了含有尿苷核苷抗生素（幼稚嘧啶，植物霉素/血小霉素/ Sansanmycins，Muraymycins，Capuramycins的结构和生物学活性，所述靶向蛋白酶MRAY在肽导蛋白生物合成途径上。特别地，描述了结构函数研究的最新进展，以及旋流酶MRAY与MURAYMYCIN D2和遗传霉素复合的X射线晶体结构。还综述了核苷抗生素和类似物相关与MRAY相关的其他磷核 - 核苷酸转移酶的抑制。

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《The Journal of Antibiotics: An International Journal》 |2019年第12期|共12页
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Bugg Timothy D. H.; Kerr Rachel V;
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Univ Warwick Dept Chem Coventry CV4 7AL W Midlands England;

Univ Warwick Dept Chem Coventry CV4 7AL W Midlands England;

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正文语种 eng
中图分类药学;
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1. Mechanism of action of nucleoside antibacterial natural product antibiotics [J] . Bugg Timothy D. H., Kerr Rachel V The Journal of Antibiotics: An International Journal . 2019,第12期

机译：核苷抗菌天然产物抗生素的作用机制
2. Muraymycin nucleoside-peptide antibiotics: uridine-derived natural products as lead structures for the development of novel antibacterial agents [J] . Daniel Wiegmann, Stefan Koppermann, Marius Wirth, Beilstein journal of organic chemistry. . 2016,第1期

机译：Muraymycin核苷肽抗生素：尿苷衍生的天然产物作为开发新型抗菌剂的先导结构
3. Inhibition of phospho-MurNAc-pentapeptide translocase (MraY) by nucleoside natural product antibiotics, bacteriophage phi X174 lysis protein E, and cationic antibacterial peptides [J] . Bugg Timothy D. H., Rodolis Maria T., Mihalyi Agnes, Bioorganic and medicinal chemistry . 2016,第24期

机译：核苷天然产物抗生素，噬菌体phi X174裂解蛋白E和阳离子抗菌肽对磷酸-MurNAc-五肽转位酶（MraY）的抑制作用
4. SYNTHESIS AND IN VITRO ANTIBACTERIAL ACTIVITY OF NATURAL ANTIMICROBIAL PEPTIDES AND CONVENTIONAL ANTIBIOTICS [C] . Wojciech. Kamysz, Piotr. Nadolski the European Peptide Symposium . 2007

机译：天然抗菌肽和常规抗生素的合成和体外抗菌活性
5. Chemical mechanisms of DNA cleavage by the antitumor antibiotic natural product leinamycin. [D] . Mitra, Kaushik. 2000

机译：抗肿瘤抗生素天然产物莱那霉素裂解DNA的化学机理。
6. Muraymycin nucleoside-peptide antibiotics: uridine-derived natural products as lead structures for the development of novel antibacterial agents [O] . Daniel Wiegmann, Stefan Koppermann, Marius Wirth, 2016

机译：Muraymycin核苷肽抗生素：尿苷衍生的天然产物作为开发新型抗菌剂的先导结构
7. Inhibition of phospho-MurNAc-pentapeptide translocase (MraY) by nucleoside natural product antibiotics, bacteriophage X174 lysis protein E, and cationic antibacterial peptides [O] . Bugg, Tim, Rodolis, Maria T., Mihalyi, Agnes, 2016

机译：核苷天然产物抗生素，噬菌体φX174裂解蛋白E和阳离子抗菌肽对磷酸-MurNAc-五肽转位酶（MraY）的抑制作用

Mechanism of action of nucleoside antibacterial natural product antibiotics

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