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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Molecular targets of biofabricated silver nanoparticles in Candida albicans
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Molecular targets of biofabricated silver nanoparticles in Candida albicans

机译：念珠菌念珠菌的生物亚铁银纳米粒子的分子靶标

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摘要

We have analyzed the expressions of genes which regulate Ras-cAMP-EFGJ and CEK1-MAPK pathways involved in yeast to hyphal form morphogenesis in Candida albicans. The expression profile of genes associated with serum-induced morphogenesis showed reduced expressions of genes involved in these pathways by the treatment with biofabricated silver nanoparticles. Cell elongation gene, ECE1, was downregulated by 5.1 fold by the treatment of silver nanoparticles. Expression of hyphal inducer gene, TEC1 was downregulated by 6.28 fold. Negative regulators of yeast to hyphal transition, TUP1 and RFG1 were downregulated by 2.45 and 5.43 fold, respectively. Current study suggests that silver nanoparticles affect gene expression and may subsequently reduce virulence in C. albicans. Targeting genes involved in virulence may be an acceptable novel treatment strategy for pathogenic fungal infections.
机译：我们分析了调节RAS-CAMP-EFGJ和CEK1-MAPK途径的基因表达，涉及酵母在Candida醛糖醛植物中的亚酚形式的形态发生。 与血清诱导的形态发生相关的基因的表达谱表现出通过用生物羧酸银纳米颗粒的处理而参与这些途径的基因表达。 通过处理银纳米粒子将细胞伸长基因ECE1下调5.1倍。 悬垂诱导物基因的表达，TEC1下调6.28倍。 酵母对亚酚型过渡的负调节剂，Tup1和RFG1分别下调2.45和5.43倍。 目前的研究表明，银纳米粒子会影响基因表达，随后可以在C.醛型人中减少毒力。 毒力所涉及的靶向基因可能是致病性真菌感染的可接受的新型治疗策略。

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