Aspermicrones A-C, novel dibenzospiroketals from the seaweed-derived endophytic fungus Aspergillus micronesiensis

Nguyen Dinh Luyen; Le Mai Huong; Tran Thi Hong Ha; Le Huu Cuong; Duong Thi Hai Yen; Nguyen Xuan Nhiem; Bui Huu Tai; Gardes Astrid; Kopprio German; Phan Van Kiem

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Aspermicrones A-C, novel dibenzospiroketals from the seaweed-derived endophytic fungus Aspergillus micronesiensis

机译：aspermicrones a-c，来自海藻衍生的内胚菌的新型二苯并卟啉毒蕈曲霉属

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Chemical investigation of the Kappaphycus alvarezii-derived endophytic fungus Aspergillus micronesiensis lead to the isolation of three novel dibenzospiroketals, aspermicrones A-C (1-3). Their chemical structures were determined by extensive analysis of HR-ESI-MS and NMR spectral data. The absolute configurations of them were determined by experimental and TD-DFT theoretical calculated circular dichroism spectra. Compound 2 exhibited selective cytotoxic effect toward HepG2 cell line (IC50 = 9.9 mu M). Additionally, both of compounds 2 and 3 displayed anti-microbial activity against Staphylococcus aureus (MIC = 123.2 mu M for each compound). Compound 1 was inactivity in both cytotoxic and antimicrobial assays.

机译：Kappaphycus Alvarezii衍生的内胚细胞曲霉属的化学研究导致三种新的Dibenzopoketals分离，Aspermicrone A-C（1-3）。通过对HR-ESI-MS和NMR光谱数据的广泛分析来确定它们的化学结构。它们的绝对配置由实验和TD-DFT理论计算的圆形二色二倍体光谱决定。化合物2表现出对HepG2细胞系的选择性细胞毒性作用（IC50 =9.9μm）。另外，两种化合物2和3都显示出对金黄色葡萄球菌的抗微生物活性（对于每种化合物，MIC =123.2μm）。化合物1在细胞毒性和抗微生物测定中处于不活动状态。

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来源
《The Journal of Antibiotics: An International Journal》 |2019年第11期|共5页
作者
Nguyen Dinh Luyen; Le Mai Huong; Tran Thi Hong Ha; Le Huu Cuong; Duong Thi Hai Yen; Nguyen Xuan Nhiem; Bui Huu Tai; Gardes Astrid; Kopprio German; Phan Van Kiem;
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作者单位

VAST Inst Nat Prod Chem 18 Hoang Quoc Viet Hanoi Vietnam;

VAST Inst Nat Prod Chem 18 Hoang Quoc Viet Hanoi Vietnam;

VAST Inst Nat Prod Chem 18 Hoang Quoc Viet Hanoi Vietnam;

VAST Inst Nat Prod Chem 18 Hoang Quoc Viet Hanoi Vietnam;

VAST Inst Marine Biochem 18 Hoang Quoc Viet Hanoi Vietnam;

VAST Grad Univ Sci &

Technol 18 Hoang Quoc Viet Hanoi Vietnam;

VAST Grad Univ Sci &

Technol 18 Hoang Quoc Viet Hanoi Vietnam;

Leibniz Ctr Trop Marine Res ZMT Fahrenheit 6 D-28359 Bremen Germany;

Leibniz Ctr Trop Marine Res ZMT Fahrenheit 6 D-28359 Bremen Germany;

VAST Grad Univ Sci &

Technol 18 Hoang Quoc Viet Hanoi Vietnam;

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正文语种 eng
中图分类药学;
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1. Aspermicrones A-C, novel dibenzospiroketals from the seaweed-derived endophytic fungus Aspergillus micronesiensis [J] . Nguyen Dinh Luyen, Le Mai Huong, Tran Thi Hong Ha, The Journal of Antibiotics: An International Journal . 2019,第11期

机译：aspermicrones a-c，来自海藻衍生的内胚菌的新型二苯并卟啉毒蕈曲霉属
2. Amichalasines A-C: Three Cytochalasan Heterotrimers from Aspergillus micronesiensis PG-1 [J] . Wu Zhaodi, Tong Qingyi, Zhang Xiaotian, Organic letters . 2019,第4期

机译：Amichalasines A-C：来自Aspergillus microssiensis的三种细胞酵母过度仪pg-1
3. Anti-phytopathogenic Bacterial Metabolites From the Seaweed-Derived Fungus Aspergillus sp. D40 [J] . Huang Rui-Huan, Lin Wei, Zhang Peng, Frontiers in Marine Science . 2020,第1期

机译：来自海藻衍生的真菌的抗植物疗法细菌代谢物。 D40.
4. Molecular Reidentification of Endophytic Fungus LBKURCC40 Isolated from Dahlia's Tuber (Dahlia Variabilis) Using the Sequence of ITS rDNA [C] . Nabella Suraya, Fiuna Piska, Nova Wahyu Pratiwi International Conference on Science, Technology, and Interdisciplinary Research . 2019

机译：使用其RDNA的序列，从大丽花的块茎（Dahlia Variabilis）中分离的内生真菌Lbkurcc40分子的分子切除
5. The development of an in vitro system to determine the role of endophytic fungus (Aspergillus ustus) on Daucus carota roots. [D] . Osuna-Avila, Pedro. 2002

机译：体外系统的开发，以确定内生真菌（uspergillus ustus）在胡萝卜胡萝卜根上的作用。
6. Phyllomeroterpenoids A-C Multi-biosynthetic Pathway Derived Meroterpenoids from the TCM Endophytic Fungus Phyllosticta sp. and their Antimicrobial Activities [O] . Heng-Gang Yang, Huan Zhao, Jiao-Jiao Li, -1

机译：毛状萜类化合物A-C来自中药内生真菌Pyllosticta sp。的多种生物合成途径。及其抗菌活性
7. Polyoxygenated polyketides from the marine-derived fungus Aspergillus micronesiensis [O] . Nguyen Dinh Luyen, Le Mai Huong, Tran Thi Hong Ha, 2019

机译：来自海洋衍生的真菌的聚氧化聚酯曲霉肽

Aspermicrones A-C, novel dibenzospiroketals from the seaweed-derived endophytic fungus Aspergillus micronesiensis

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