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Discovery and applications of nucleoside antibiotics beyond polyoxin

机译:核苷抗生素超越多氧化茄的发现和应用

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摘要

Nucleoside antibiotics possess various biological activities such as antibacterial, antifungal, anticancer, and herbicidal activities. RIKEN scientists contributed to this area of research with two representative antifungal nucleoside antibiotics, blasticidin S and polyoxin. Blasticidin S was the first antibiotic exploited in agriculture worldwide. Meanwhile, the polyoxins discovered by Isono and Suzuki are still used globally as an agricultural antibiotic. In this review article, the research on nucleoside antibiotics mainly done by Isono and his collaborators is summarized from the discovery of polyoxin to subsequent investigations.
机译:核苷抗生素具有各种生物活性,例如抗菌,抗真菌,抗癌和除草活性。 RIKEN科学家们为这一研究领域贡献了两个代表性抗真菌核苷抗生素,Blastasticin S和Polyoxin。 Blasterastidin S是全球农业爆炸的第一个抗生素。 同时,由Isono和Suzuki发现的多氧化胍仍然作为农业抗生素全球使用。 在本文中,核苷酸抗生素的研究主要由ISONO和他的合作者概括为多氧化胍与随后的调查。

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