首页> 外文期刊>The Journal of Antibiotics: An International Journal >Antiviral effect of sinefungin on in vitro growth of feline herpesvirus type 1
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Antiviral effect of sinefungin on in vitro growth of feline herpesvirus type 1

机译:Sinefungin对猫卵磷脂体外体外生长的抗病毒作用1

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摘要

Feline herpesvirus type 1 (FHV-1) causes a potentially fatal disease in cats. Through the use of virus inhibition and cytotoxicity assays, sinefungin, a nucleoside antibiotic, was assessed for its potential to inhibit the growth of FHV-1. Sinefungin inhibited in vitro growth of FHV-1 most significantly over other animal viruses, such as feline infectious peritonitis virus, equine herpesvirus, pseudorabies virus and feline calicivirus. Our results revealed that sinefungin specifically suppressed the replication of FHV-1 after its adsorption to the host feline kidney cells in a dose-dependent manner without obvious cytotoxicity to the host cells. This antibiotic can potentially offer a highly effective treatment for animals infected with FHV-1, providing alternative medication to currently available antiviral therapies.
机译:猫西疱病毒型1(FHV-1)导致猫的潜在致命疾病。 通过使用病毒抑制和细胞毒性测定,评估Sinefungin,核苷抗生素,用于抑制FHV-1的生长。 Sinefungin在其他动物病毒中最显着抑制FHV-1的体外生长,例如猫传染性腹膜炎病毒,马疱疹病毒,伪症病毒和猫科学。 我们的研究结果表明,Sinefungin特别抑制了以剂量依赖性方式吸附到宿主哺乳线肾细胞后的FHV-1的复制,而没有明显细胞毒性对宿主细胞。 这种抗生素可能为感染FHV-1感染的动物提供高效的治疗,为目前可用的抗病毒疗法提供替代药物。

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