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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Sch 1385568, a new azaphilone from Aspergillus sp.
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Sch 1385568, a new azaphilone from Aspergillus sp.

机译：SCH 1385568，来自Aspergillus sp的新的azaphilone。

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摘要

In the course of our continuing search for novel antimicrobial agents,1,2 we have identified a novel azaphilone Sch 1385568 (1) (Scheme 1) from an Aspergillus sp. culture (SPRI-0814). Various azaphilones and hydrogenated azaphilones have been isolated mainly from fungal species, such as Emericella sp.,3"5 Penicillium sp.,6"8 Phomopsis sp.,9 Chaetomium sp.,10 Pseudohalonectria sp.11 and Anuu-lohypoxylon sp.12 Some of them have been described to show biological activities against various targets related to the different therapeutic areas, including cardiovascular, lipid metabolism, inflammatory, anti-infectious and antitumor areas. More specifically, azaphilones have been reported to display inhibitory activity against the following targets: acyl-CoA: cholesterol acyltransferase,6 endothelin receptor,8 cholesteryl ester transfer protein,13 platelet-derived growth factor,14 gp120-CD4,15 monoamine oxidase,16 phospholipase A217 and nitric oxide production.18 Some azaphilones have also been reported to display antitumor10,19 and antimicrobial activities.10"12 In this communication, we describe the fermentation, isolation, structure elucidation and antimicrobial activity of 1.
机译：在我们继续寻找新型抗微生物剂的过程中，1,2我们已经鉴定了一种来自Aspergillus SP的新型类萘酮SCH 1385568（1）（方案1）。文化（Spri-0814）。各种共苯胺和氢化的三叶酮主要从真菌物种中分离，例如Emericella sp.，3“5 penicillium sp。，8”8.38phomopsis sp。，9 chaetomium sp.11和Anuu-lohypoxylon sp.11和Anuu-lohypoxylon sp.12已经描述了其中一些以显示针对与不同治疗区域相关的各种目标的生物学活动，包括心血管，脂质代谢，炎症，抗传染性和抗肿瘤区域。更具体地说，据报道，共苯甲酸酮展示针对以下靶标的抑制活性：酰基-CoA：胆固醇酰酰转移酶，6个内皮素受体，8个胆汁纤维酯转移蛋白，13个血小板衍生的生长因子，14 gp120-CD4,15单胺氧化酶，16磷脂酶A217和一氧化氮产生.18还据报道一些共磷酸酮展示抗肿瘤10,19和抗微生物活性.10“12在这种通信中，我们描述了1的发酵，分离，结构阐明和抗微生物活性。

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