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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Sch 1385568, a new azaphilone from Aspergillus sp.
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Sch 1385568, a new azaphilone from Aspergillus sp.

机译：Sch 1385568，来自曲霉属（Aspergillus sp。）的新型氮杂苯甲酮。

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摘要

In the course of our continuing search for novel antimicrobial agents,1,2 we have identified a novel azaphilone Sch 1385568 (1) (Scheme 1) from an Aspergillus sp. culture (SPRI-0814). Various azaphilones and hydrogenated azaphilones have been isolated mainly from fungal species, such as Emericella sp.,3"5 Penicillium sp.,6"8 Phomopsis sp.,9 Chaetomium sp.,10 Pseudohalonectria sp.11 and Anuu-lohypoxylon sp.12 Some of them have been described to show biological activities against various targets related to the different therapeutic areas, including cardiovascular, lipid metabolism, inflammatory, anti-infectious and antitumor areas. More specifically, azaphilones have been reported to display inhibitory activity against the following targets: acyl-CoA: cholesterol acyltransferase,6 endothelin receptor,8 cholesteryl ester transfer protein,13 platelet-derived growth factor,14 gp120-CD4,15 monoamine oxidase,16 phospholipase A217 and nitric oxide production.18 Some azaphilones have also been reported to display antitumor10,19 and antimicrobial activities.10"12 In this communication, we describe the fermentation, isolation, structure elucidation and antimicrobial activity of 1.
机译：在我们不断寻找新型抗菌剂的过程中，1,2，我们从曲霉属菌种中鉴定了一种新型的azaphilone Sch 1385568（1）（方案1）。文化（SPRI-0814）。主要从真菌物种中分离出各种氮杂苯甲酮和氢化的氮杂苯甲酮，例如，Emericella sp。，3“ 5 Penicillium sp。，6” 8 Phomopsis sp。，9 Chaetomium sp。，10 Pseudohalonectria sp.11和Anuu-lohypoxylon sp.12已描述其中一些对与不同治疗领域有关的各种靶标具有生物活性，这些靶标包括心血管，脂质代谢，炎症，抗感染和抗肿瘤领域。更具体地说，据报道，氮杂苯甲酮对以下靶标具有抑制活性：酰基辅酶A：胆固醇酰基转移酶，6内皮素受体，8胆固醇酯转移蛋白，13血小板衍生的生长因子，14 gp120-CD4、15单胺氧化酶，16磷脂酶A217和一氧化氮的产生。18据报道，某些氮杂苯甲酮还具有抗肿瘤作用10、19和抗菌活性。10“ 12在本文中，我们描述了1.的发酵，分离，结构解析和抗菌活性。

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