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Antibiotics in microbial coculture

机译:微生物共培养中的抗生素

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摘要

Today, the frequency of discovery of new antibiotics in microbial culture is significantly decreasing. The evidence from whole-genome surveys suggests that many genes involved in the synthesis of unknown metabolites do exist but are not expressed under conventional cultivation conditions. Therefore, it is urgently necessary to study the conditions that make otherwise silent genes active in microbes. Here we overview the knowledge on the antibiotic production promoted by cocultivation of multiple microbial strains. Accumulating evidence indicates that cocultivation can be an effective way to stimulate the production of substances that are not formed during pure cultivation. Characterization of the promotive factors produced by stimulator strains is expected to give clues to the development of effective cultivation conditions for drug discovery.
机译:如今,在微生物培养中发现新抗生素的发现频率显着降低。 来自全基因组调查的证据表明,许多参与合成未知代谢物的基因确实存在,但在常规培养条件下不表达。 因此,迫切需要研究在微生物中活跃的其他沉默基因的条件。 在这里,我们概述了多种微生物菌株的促进促进的抗生素生产的知识。 积累证据表明,共和国可以是刺激在纯培养期间未形成的物质产生的有效途径。 预期刺激菌株产生的促进因子的表征预计将为药物发现的有效培养条件的发展提供线索。

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