Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae

Watanabe Yoshihiro; Suga Takuya; Narusawa Satomi; Iwatsuki Masato; Nonaka Kenichi; Nakashima Takuji; Shinohara Yasuo; Shiotsuki Takahiro; Ichimaru Naoya; Miyoshi Hideto; Asami Yukihiro; Omura Satoshi; Shiomi Kazuro

首页> 外文期刊>The Journal of Antibiotics: An International Journal >Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae

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Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae

机译：DeNataMariic acid，一种使用药物敏感酵母菌酿酒酵母发现的新型线粒体呼吸抑制剂

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A new decalin, decatamariic acid, was isolated from a cultured broth of the fungus Aspergillus tamarii FKI-6817. Its absolute configuration was elucidated by NMR and electronic circular dichroism. Decatamariic acid (10 mu m) elicited similar to 50% inhibition of the ATP production in mitochondria isolated from wild-type Saccharomyces cerevisiae without affecting the activities of respiratory enzymes. The action manner of this compound may be interesting as a possible seed for new pesticides.

机译：从真菌曲霉葡萄牙葡萄枪的培养的肉汤中分离出一种新的十分氢萘啶醇。其绝对配置被NMR和电子圆形二色性阐明。在不影响呼吸酶的活性的情况下，脱田酸（10μm）引发了与野生型酿酒酵母中分离的大粒细胞抑制的50％抑制。该化合物的动作方式可能是有趣的，作为新农药的可能种子。

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来源
《The Journal of Antibiotics: An International Journal》 |2017年第4期|共5页
作者
Watanabe Yoshihiro; Suga Takuya; Narusawa Satomi; Iwatsuki Masato; Nonaka Kenichi; Nakashima Takuji; Shinohara Yasuo; Shiotsuki Takahiro; Ichimaru Naoya; Miyoshi Hideto; Asami Yukihiro; Omura Satoshi; Shiomi Kazuro;
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作者单位

Kitasato Univ Grad Sch Infect Control Sci Dept Drug Discovery Sci Tokyo Japan;

Kitasato Univ Kitasato Inst Life Sci Tokyo Japan;

Kitasato Univ Kitasato Inst Life Sci Tokyo Japan;

Kitasato Univ Grad Sch Infect Control Sci Dept Drug Discovery Sci Tokyo Japan;

Kitasato Univ Grad Sch Infect Control Sci Dept Drug Discovery Sci Tokyo Japan;

Kitasato Univ Grad Sch Infect Control Sci Dept Drug Discovery Sci Tokyo Japan;

Univ Tokushima Inst Genome Res Tokushima Japan;

Natl Agr &

Food Res Org Inst Agrobiol Sci Ibaraki Japan;

Kyoto Gakuen Univ Fac Bioenvironm Sci Kyoto Japan;

Kyoto Univ Grad Sch Agr Div Appl Life Sci Kyoto Japan;

Kitasato Univ Grad Sch Infect Control Sci Dept Drug Discovery Sci Tokyo Japan;

Kitasato Univ Kitasato Inst Life Sci Tokyo Japan;

Kitasato Univ Grad Sch Infect Control Sci Dept Drug Discovery Sci Tokyo Japan;

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正文语种 eng
中图分类药学;
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1. Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae [J] . Watanabe Yoshihiro, Suga Takuya, Narusawa Satomi, The Journal of Antibiotics: An International Journal . 2017,第4期

机译：DeNataMariic acid，一种使用药物敏感酵母菌酿酒酵母发现的新型线粒体呼吸抑制剂
2. Ascosteroside D, a new mitochondrial respiration inhibitor discovered by pesticidal screening using insect ADP/ATP carrier protein-expressing Saccharomyces cerevisiae [J] . Watanabe Yoshihiro, Asami Yukihiro, Narusawa Satomi, The Journal of Antibiotics: An International Journal . 2018,第1期

机译：亚脑脑内酯D，使用昆虫ADP / ATP载体蛋白表达酿酒酵母的杀虫剂筛选发现了一种新的线粒体呼吸抑制剂
3. Ascosteroside C, a new mitochondrial respiration inhibitor discovered by pesticidal screening using recombinant Saccharomyces cerevisiae. [J] . Takuya Suga, Yukihiro Asami, Shohei Hashimoto, The Journal of Antibiotics: An International Journal . 2015,第10期

机译：Ascosteroside C是一种新的线粒体呼吸抑制剂，通过使用重组酿酒酵母进行农药筛选而发现。
4. Domestication and Screening of Saccharomyces Cerevisiae Strain Resistant to Inhibitors in Lignocellulosic Hydrolysates by Acclimatizing Inhibitory [C] . Shaohua Luo, Yongwen Huang, An Chen, REET 2013 . 2014

机译：通过适应抑制抑制性抑制剂对木质纤维素水解产物抑制剂的驯化和筛选
5. The role of mitochondrial respiration and oxygen radical production in the toxicity of doxorubicin, daunorubicin and mitoxantrone in the yeast Saccharomyces cerevisiae [D] . Kule, Chris Edward 1995

机译：线粒体呼吸作用和氧自由基的产生在酵母中对阿霉素，柔红霉素和米托蒽醌的毒性作用
6. Over-expression of COQ10 in Saccharomyces cerevisiae inhibits mitochondrial respiration [O] . Mariana A. Zampol, Cleverson Busso, Fernando Gomes, -1

机译：COQ10的在酿酒酵母中抑制线粒体呼吸过度表达
7. Over-expression of COQ10 in Saccharomyces cerevisiae inhibits mitochondrial respiration [O] . ZAMPOL, Mariana A., BUSSO, Cleverson, GOMES, Fernando, 2010

机译：酿酒酵母中COQ10的过量表达抑制线粒体呼吸

Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae

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