Ascosteroside D, a new mitochondrial respiration inhibitor discovered by pesticidal screening using insect ADP/ATP carrier protein-expressing Saccharomyces cerevisiae

Watanabe Yoshihiro; Asami Yukihiro; Narusawa Satomi; Hashimoto Shohei; Iwatsuki Masato; Nonaka Kenichi; Shinohara Yasuo; Shiotsuki Takahiro; Ichimaru Naoya; Miyoshi Hideto; Omura Satoshi; Shiomi Kazuro

首页> 外文期刊>The Journal of Antibiotics: An International Journal >Ascosteroside D, a new mitochondrial respiration inhibitor discovered by pesticidal screening using insect ADP/ATP carrier protein-expressing Saccharomyces cerevisiae

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Ascosteroside D, a new mitochondrial respiration inhibitor discovered by pesticidal screening using insect ADP/ATP carrier protein-expressing Saccharomyces cerevisiae

机译：亚脑脑内酯D，使用昆虫ADP / ATP载体蛋白表达酿酒酵母的杀虫剂筛选发现了一种新的线粒体呼吸抑制剂

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A new lanostane-type triterpenoid, ascosteroside D, was isolated from a fungus, Aspergillus sp. FKI-6682. It inhibited insect ADP/ATP carrier protein (AAC)-expressing Saccharomyces cerevisiae in glycerol-containing medium, but did not inhibit Delta aac S. cerevisiae in glucose-containing medium. It is hypothesized that ascosteroside D inhibits ATP production in mitochondria.

机译：新的Lanostane型三萜类化合物，亚腹腺苷D从真菌，曲霉SP中分离出来。 FKI-6682。它抑制昆虫ADP / ATP载体蛋白（AAC） - 在含甘油培养基中的酿酒酵母酿酒酵母，但在含葡萄糖培养基中没有抑制Delta Aac S. Cerevisiae。假设亚脑脑皂甙D抑制线粒体中的ATP产量。

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《The Journal of Antibiotics: An International Journal》 |2018年第1期|共3页
作者
Watanabe Yoshihiro; Asami Yukihiro; Narusawa Satomi; Hashimoto Shohei; Iwatsuki Masato; Nonaka Kenichi; Shinohara Yasuo; Shiotsuki Takahiro; Ichimaru Naoya; Miyoshi Hideto; Omura Satoshi; Shiomi Kazuro;
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作者单位

Kitasato Univ Grad Sch Infect Control Sci Tokyo Japan;

Kitasato Univ Grad Sch Infect Control Sci Tokyo Japan;

Kitasato Univ Sch Sci Dept Chem Sagamihara Kanagawa Japan;

Kitasato Univ Sch Sci Dept Chem Sagamihara Kanagawa Japan;

Kitasato Univ Grad Sch Infect Control Sci Tokyo Japan;

Kitasato Univ Grad Sch Infect Control Sci Tokyo Japan;

Tokushima Univ Inst Genome Res Tokushima Japan;

Natl Inst Agrobiol Sci Insect Growth Regulat Res Unit Ibaraki Japan;

Kyoto Gakuen Univ Fac Bioenvironm Sci Kyoto Japan;

Kyoto Univ Grad Sch Agr Div Appl Life Sci Kyoto Japan;

Kitasato Univ Kitasato Inst Life Sci Tokyo Japan;

Kitasato Univ Grad Sch Infect Control Sci Tokyo Japan;

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正文语种 eng
中图分类药学;
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1. Ascosteroside D, a new mitochondrial respiration inhibitor discovered by pesticidal screening using insect ADP/ATP carrier protein-expressing Saccharomyces cerevisiae [J] . Watanabe Yoshihiro, Asami Yukihiro, Narusawa Satomi, The Journal of Antibiotics: An International Journal . 2018,第1期

机译：亚脑脑内酯D，使用昆虫ADP / ATP载体蛋白表达酿酒酵母的杀虫剂筛选发现了一种新的线粒体呼吸抑制剂
2. Ascosteroside C, a new mitochondrial respiration inhibitor discovered by pesticidal screening using recombinant Saccharomyces cerevisiae. [J] . Takuya Suga, Yukihiro Asami, Shohei Hashimoto, The Journal of Antibiotics: An International Journal . 2015,第10期

机译：Ascosteroside C是一种新的线粒体呼吸抑制剂，通过使用重组酿酒酵母进行农药筛选而发现。
3. Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae [J] . Watanabe Yoshihiro, Suga Takuya, Narusawa Satomi, The Journal of Antibiotics: An International Journal . 2017,第4期

机译：DeNataMariic acid，一种使用药物敏感酵母菌酿酒酵母发现的新型线粒体呼吸抑制剂
4. Domestication and Screening of Saccharomyces Cerevisiae Strain Resistant to Inhibitors in Lignocellulosic Hydrolysates by Acclimatizing Inhibitory [C] . Shaohua Luo, Yongwen Huang, An Chen, REET 2013 . 2014

机译：通过适应抑制抑制性抑制剂对木质纤维素水解产物抑制剂的驯化和筛选
5. ADP/ATP Carrier Activity and Mitochondrial Translation-Dependent Regulation of Oxidative Phosphorylation in Saccharomyces cerevisiae [D] . Ogunbona, Oluwaseun Basit. 2018

机译：啤酒酵母中的ADP / ATP载体活性和线粒体翻译依赖的氧化磷酸化调控。
6. Deletion or Overexpression of Mitochondrial NAD+ Carriers in Saccharomyces cerevisiae Alters Cellular NAD and ATP Contents and Affects Mitochondrial Metabolism and the Rate of Glycolysis [O] . Gennaro Agrimi, Luca Brambilla, Gianni Frascotti, 2011

机译：酿酒酵母中线粒体NAD +载体的缺失或过表达改变细胞NAD和ATP含量并影响线粒体代谢和糖酵解速率
7. Expression of the AAC2 Gene Encoding the Major Mitochondrial ADP/ATP Carrier in Saccharomyces cerevisiae is Controlled at the Transcriptional Level by Oxygen, Heme and HAP2 Factor [O] . Svätopluk Betina, Gabriela Gavurníková, Peter Haviernik, 2008

机译：编码在酿酒酵母中编码主要线粒体ADP / ATP载体的AAC2基因的表达在通过氧气，血红素和HAP2因子进行转录水平控制酿酒酵母

Ascosteroside D, a new mitochondrial respiration inhibitor discovered by pesticidal screening using insect ADP/ATP carrier protein-expressing Saccharomyces cerevisiae

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