Tyropeptins, proteasome inhibitors produced by Kitasatospora sp MK993-dF2

Momose Isao; Watanabe Takumi

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Tyropeptins, proteasome inhibitors produced by Kitasatospora sp MK993-dF2

机译：酪蛋白，由Kitasatospora SP MK993-DF2产生的蛋白酶体抑制剂

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Tyropeptins are new proteasome inhibitors isolated from the culture broth of Kitasatospora sp. MK993-dF2. Tyropeptins permeate cell membranes, inhibit intracellular proteasomes and reduce the degradation of ubiquitinated proteins in mammalian cells. We performed structure-based drug design and structure-activity relationship studies on tyropeptin derivatives to obtain valuable information of derivatives. Among the synthesized tyropeptin derivatives, some boronic acid derivatives exhibited potent antitumor effects against human multiple myeloma. In this review, we summarize the discovery of tyropeptins and the development of tyropeptin derivatives.

机译：酪粉蛋白是从Kitasatospora sp的培养肉汤中分离的新蛋白酶体抑制剂。 MK993-DF2。 Tyropeptins渗透细胞膜，抑制细胞内蛋白质，并降低哺乳动物细胞中染色蛋白质的降解。我们对酪蛋白衍生物进行了基于结构的药物设计和结构 - 活性关系研究，以获得衍生物的宝贵信息。在合成的酪蛋白衍生物中，一些硼酸衍生物表现出对人多发性骨髓瘤的有效抗肿瘤作用。在这篇综述中，我们总结了酪蛋白的发现和酪蛋白衍生物的发展。

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《The Journal of Antibiotics: An International Journal》 |2017年第5期|共9页
作者
Momose Isao; Watanabe Takumi;
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Inst Microbial Chem BIKAKEN Shizuoka Japan;

Inst Microbial Chem BIKAKEN Tokyo Japan;

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正文语种 eng
中图分类药学;
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1. Tyropeptins, proteasome inhibitors produced by Kitasatospora sp MK993-dF2 [J] . Momose Isao, Watanabe Takumi The Journal of Antibiotics: An International Journal . 2017,第5期

机译：酪蛋白，由Kitasatospora SP MK993-DF2产生的蛋白酶体抑制剂
2. Tyropeptins A and B, New Proteasome Inhibitors Produced by Kitasatospora sp. MK993-dF2 I. Taxomomy, Isolation, Physico-chemical Properties and Biological Activities [J] . Isao Momose, Ryuichi Sekizawa, Hideki Hashiume, The Journal of Antibiotics: An International Journal . 2001,第12期

机译：酪蛋白A和B，Kitasatospora sp。生产的新型蛋白酶体抑制剂。 MK993-dF2 IN。分类学，分离，理化性质和生物活性
3. Tyropeptins A and B, New Proteasome Inhibitors Produced by Kitasatospora sp. MIK 993-dF2 [J] . Isao Momose, Ryuichi Sekizawa, Sehei Hirosawa, The Journal of Antibiotics: An International Journal . 2001,第12期

机译：酪蛋白A和B，Kitasatospora sp。生产的新型蛋白酶体抑制剂。 MIK 993-dF2
4. Enzymatic hydrolysis of lignocellulosic biomass by Kitasatospora sp. to produce xylo-oligosaccharides (XOS) [C] . Nanik Rahmani, Alifah Mafatikhul Jannah, Puspita Lisdiyanti, International Symposium on Applied Chemistry . 2017

机译：Kitasatospora sp的木质纤维素生物量的酶水解。生产Xylo-Oligosaccharide（XOS）
5. The Design and Synthesis of Novel Proteasome Inhibitors: Studies on the Synthesis of Nagelamide M and Analogs, the Synthesis of Rapamycin Based Proteasome Inhibitors, and the Synthesis of TCH Based Molecular Probes for Binding Site Determination. [D] . Giletto, Matthew Basil. 2017

机译：新型蛋白酶体抑制剂的设计与合成：Nagelamide M和类似物的合成，雷帕霉素基蛋白酶体抑制剂的合成以及TCH基分子探针的结合位点测定的研究。
6. Antitumor effects of tyropeptin-boronic acid derivatives: New proteasome inhibitors [O] . Isao Momose, Hikaru Abe, Takumi Watanabe, 2014

机译：酪肽素-硼酸衍生物的抗肿瘤作用：新型蛋白酶体抑制剂
7. Tyropeptins, proteasome inhibitors produced by Kitasatospora sp. MK993-dF2 [O] . Isao Momose, Takumi Watanabe 2017

机译：酪蛋白，Kitasatospora sp产生的蛋白酶体抑制剂。 MK993-DF2.

Tyropeptins, proteasome inhibitors produced by Kitasatospora sp MK993-dF2

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