The ups and downs of drug discovery: the early history of Fidaxomicin

McAlpine James B.

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The ups and downs of drug discovery: the early history of Fidaxomicin

机译：药物发现的起伏：Fidaxomicin的早期历史

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The path from antibiotic compound discovery to the market is marked by many potholes and its negotiation is often dependent on luck and persistence. Perhaps the prime example of this is the case of the development of tiacumicin B to Fidaxomicin, where both parameters were critical and the path was particularly circuitous.

机译：抗生素复合发现对市场的路径标志着许多坑洼，其谈判往往依赖运气和持久性。也许这方面的典型例子是Tiacumic蛋白B到Fidaxomicin的情况的情况，其中两个参数都是关键的，路径特别迂回。

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《The Journal of Antibiotics: An International Journal》 |2017年第5期|共3页
作者
McAlpine James B.;
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作者单位

Univ Illinois Coll Pharm Dept Med Chem &

Pharmacognosy 833 South Wood St Chicago IL 60612 USA;

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原文格式 PDF
正文语种 eng
中图分类药学;
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1. The ups and downs of drug discovery: the early history of Fidaxomicin [J] . McAlpine James B. The Journal of Antibiotics: An International Journal . 2017,第5期

机译：药物发现的起伏：Fidaxomicin的早期历史
2. Antimicrobial drug discovery: lessons of history and future strategies [J] . Anthony Travis Expert opinion on drug discovery . 2018,第7a12期

机译：抗菌药物发现：历史和未来策略的课程
3. History of antimicrobial drug discovery: Major classes and health impact [J] . Aminov Rustam Biochemical Pharmacology . 2017,第期

机译：抗菌药物发现的历史：主要课程和健康影响
4. Causality Discovery with Domain Knowledge for Drug-Drug Interactions Discovery [C] . Sitthichoke Subpaiboonkit, Xue Li, Xin Zhao, International Conference on Advanced Data Mining and Applications . 2019

机译：具有域知识的因果关系发现，用于药物相互作用
5. Discovery and analysis of patterns in molecular networks: Link prediction, network analysis, and applications to novel drug target discovery. [D] . Zhang, Minlu. 2012

机译：在分子网络中发现和分析模式：链接预测，网络分析以及在新型药物靶点发现中的应用。
6. A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research [O] . Gareth J. Sanger, Paul L. R. Andrews 2018

机译：治疗恶心和呕吐的药物发现史及其对未来研究的启示
7. On the history of biological drugs: the true discovery of the IL-1 receptor antagonist On the history of biological drugs: the true discovery of the IL-1 receptor antagonist [O] . P. Marson, L. Punzi 2012

机译：关于生物药物的历史：IL-1受体拮抗剂的真实发现关于生物药物的历史：IL-1受体拮抗剂的真实发现
8. Discovery of the tau lepton: Part 1, The early history through 1975; Part 2, Confirmation of the discovery and measurement of major properties, 1976--1982 [R] . Perl, M. L. 1994

机译：发现轻微的轻子：第1部分，1975年的早期历史;第2部分，确认主要特性的发现和测量，1976--1982

The ups and downs of drug discovery: the early history of Fidaxomicin

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