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首页> 外文期刊>The Journal of Antibiotics: An International Journal >New anti-inflammatory metabolites produced by Streptomyces violaceoruber isolated from Equus burchelli feces
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New anti-inflammatory metabolites produced by Streptomyces violaceoruber isolated from Equus burchelli feces

机译：由Empus Burchelli粪便分离的Streptomyces violachoruber生产的新的抗炎代谢物

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摘要

Three new metabolites (2-4), together with one known compound, GTRI-02, (1) were isolated from a fermentation broth of Streptomyces violaceoruber derived from Equus burchelli feces. The structures of the new compounds 2-4 were established using comprehensive NMR spectroscopic data analysis as well as UV, IR and MS data. The anti-inflammatory activity of compounds 1-4 was tested by examining their ability to inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. Compound 2 showed a moderate inhibition of NO production with IC50 value of 51.2 mu M.
机译：三种新的代谢物（2-4）与一种已知的化合物，GTRI-02，（1）分离出从Qualus Burchelli粪便的链霉菌属植物的发酵汤中分离出来。 使用综合的NMR光谱数据分析以及UV，IR和MS数据建立新化合物2-4的结构。 通过检查其抑制脂多糖（LPS）制备的一氧化物（NO）生产的能力来测试化合物1-4的抗炎活性。 化合物2显示出对NO生产的适度抑制，IC50值为51.2μm。

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    Ma Jian; Lei Hui; Chen Xiu; Bi Xiaoxu; Jiang Yi; Han Li; Huang Xueshi;

  • 作者单位

    Northeastern Univ Coll Life &

    Hlth Sci Inst Microbial Pharmaceut Wenhua Rd 3-11 Shenyang 110819;

    Northeastern Univ Coll Life &

    Hlth Sci Inst Microbial Pharmaceut Wenhua Rd 3-11 Shenyang 110819;

    Yunnan Univ Yunnan Inst Microbiol Sch Life Sci Kunming 650091 Yunnan Peoples R China;

    Northeastern Univ Coll Life &

    Hlth Sci Inst Microbial Pharmaceut Wenhua Rd 3-11 Shenyang 110819;

    Yunnan Univ Yunnan Inst Microbiol Sch Life Sci Kunming 650091 Yunnan Peoples R China;

    Northeastern Univ Coll Life &

    Hlth Sci Inst Microbial Pharmaceut Wenhua Rd 3-11 Shenyang 110819;

    Northeastern Univ Coll Life &

    Hlth Sci Inst Microbial Pharmaceut Wenhua Rd 3-11 Shenyang 110819;

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  • 正文语种 eng
  • 中图分类 药学;
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