Valgamicin C, a novel cyclic depsipeptide containing the unusual amino acid cleonine, and related valgamicins A, T and V produced by Amycolatopsis sp ML1-hF4

Hashizume Hideki; Iijima Kiyoko; Yamashita Kazuma; Kimura Tomoyuki; Wada Shun-ichi; Sawa Ryuichi; Igarashi Masayuki

首页> 外文期刊>The Journal of Antibiotics: An International Journal >Valgamicin C, a novel cyclic depsipeptide containing the unusual amino acid cleonine, and related valgamicins A, T and V produced by Amycolatopsis sp ML1-hF4

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Valgamicin C, a novel cyclic depsipeptide containing the unusual amino acid cleonine, and related valgamicins A, T and V produced by Amycolatopsis sp ML1-hF4

机译：valgamicin c，一种含有异常氨基酸的新型循环脂蛋白，以及由amycolatopsis sp ml1-hf4产生的相关valgamicins a，t和v

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In the course of optimizing pargamicin A production in Amycolatopsis sp. ML1-hF4, we discovered novel cyclic depsipeptide compounds in the broth and designated them valgamicins A, C, T and V. The structures of these molecules were determined by spectroscopic studies, advanced Marfey's method and X-ray crystal structural analysis. Valgamicin C contains the extremely rare amino acid cleonine. To our knowledge, this is the first report of a cleonine-containing metabolite from a naturally isolated microorganism without any breeding or mutation treatment. None of the valgamicins showed potent antibacterial activity against either Gram-positive or-negative bacteria. Valgamicins A, C and T exhibited moderate cytotoxicity against human tumor cell lines.

机译：在优化Pargamicin Amycolatopsis SP中的生产过程中。我们在肉汤中发现了新型的循环羟基肽化合物，并指定它们valgamicins A，C，T和V.这些分子的结构通过光谱研究，先进的Marfey的方法和X射线晶体结构分析来确定。 Valgamicin C含有极稀有的氨基酸克隆。据我们所知，这是来自天然孤立的微生物的含麦克宁代谢物的第一报告，没有任何繁殖或突变治疗。 valgamicins都没有针对革兰氏阳性或阴性细菌表现出有效的抗菌活性。 Valgamicins A，C和T表现出对人肿瘤细胞系的中度细胞毒性。

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来源
《The Journal of Antibiotics: An International Journal》 |2018年第1期|共6页
作者
Hashizume Hideki; Iijima Kiyoko; Yamashita Kazuma; Kimura Tomoyuki; Wada Shun-ichi; Sawa Ryuichi; Igarashi Masayuki;
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BIKAKEN Inst Microbial Chem Tokyo Japan;

BIKAKEN Inst Microbial Chem Tokyo Japan;

BIKAKEN Inst Microbial Chem Tokyo Japan;

BIKAKEN Inst Microbial Chem Tokyo Japan;

BIKAKEN Inst Microbial Chem Tokyo Japan;

BIKAKEN Inst Microbial Chem Tokyo Japan;

BIKAKEN Inst Microbial Chem Tokyo Japan;

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正文语种 eng
中图分类药学;
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1. Valgamicin C, a novel cyclic depsipeptide containing the unusual amino acid cleonine, and related valgamicins A, T and V produced by Amycolatopsis sp ML1-hF4 [J] . Hashizume Hideki, Iijima Kiyoko, Yamashita Kazuma, The Journal of Antibiotics: An International Journal . 2018,第1期

机译：valgamicin c，一种含有异常氨基酸的新型循环脂蛋白，以及由amycolatopsis sp ml1-hf4产生的相关valgamicins a，t和v
2. Turnagainolides A and B, cyclic depsipeptides produced in culture by a Bacillus sp.: isolation, structure elucidation, and synthesis. [J] . Li D, Carr G, Zhang Y, Journal of natural products . 2011,第5期

机译：Turnagainolides A和B，由芽孢杆菌在培养中产生的环状十肽：分离，结构阐明和合成。
3. Effects of amino acids and chirality for molecular folding of desoxaroline-ascidiacyclamide derivatives: X-ray crystal structures of four cyclic octapeptides including unusual amino acids, cyclo(-Ile-aThr-D-Val-Thz-)(2), cyclo(-Ala-aThr-D-Val-Thz-Ile [J] . Asano A., Kobayashi K., Arimoto M., Biopolymers: Original Research on Biomolecules and Biomolecular Assemblies . 2001,第3期

机译：氨基酸和手性对去氧杂恶啉-水杨酸环酰胺衍生物分子折叠的影响：四个环状八肽的X射线晶体结构，包括不寻常的氨基酸，环（-Ile-aThr-D-Val-Thz-）（2），环（- Ala-aThr-D-Val-Thz-Ile
4. ExD fragmentation of peptides containing beta-amino acids including isoaspartate and cyclic beta-amino acids [C] . Nadezda P. Sargaeva, Cheng Lin, Konstantin Aizikov, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：含有β-氨基酸的肽的蛋白质的碎片化，包括异菠寨酸盐和环状β-氨基酸
5. Syntheses of trifluoromethyl-containing amino acids and development of catalysts capable of hydrolyzing the D-Ala-D-Lac depsipeptide. [D] . Fichera, Alfio. 2004

机译：含三氟甲基氨基酸的合成和能够水解D-Ala-D-Lac十肽的催化剂的开发。
6. Synthesis of the Unnatural Amino Acid AGDHE a Constituent of the Cyclic Depsipeptides Callipeltins A and D [O] . Jason C. Thoen, Ángel I. Morales-Ramos, Mark A. Lipton -1

机译：非天然氨基酸AGDHE的合成环状Deptipepteptides Callipeltins A和D的组成部分
7. Amycolatopsis roodepoortensis sp. nov. and Amycolatopsis speibonae sp. nov.: antibiotic-producing actinobacteria isolated from South African soils [O] . Gareth J Everest, Marilize le Roes-Hill, Jeffrey Rohland, 2014

机译：amycolatopsis roodopsis sp。 11月。和amycolatopsis speibonae sp。 11月：从南非土壤中孤立的抗生素产生的actinobacteria
8. Unusual Magnetic Properties in Two Copper(II) Chelates of Schiff Bases Derived from Alpha-Amino Acids: A Dimeric Interaction in a Structural Linear Chain. [R] . Estes, W. E., Hatfield, W. E. 1978

机译：两种来自α-氨基酸的席夫碱铜（II）螯合物的异常磁性：结构线性链中的二聚体相互作用。

Valgamicin C, a novel cyclic depsipeptide containing the unusual amino acid cleonine, and related valgamicins A, T and V produced by Amycolatopsis sp ML1-hF4

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