JBIR-150, a novel 20-membered polyene macrolactam from marine-derived Streptomyces sp OPMA00071

Kawahara Teppei; Fujiwara Takeshi; Kagaya Noritaka; Shin-ya Kazuo

首页> 外文期刊>The Journal of Antibiotics: An International Journal >JBIR-150, a novel 20-membered polyene macrolactam from marine-derived Streptomyces sp OPMA00071

【24h】

JBIR-150, a novel 20-membered polyene macrolactam from marine-derived Streptomyces sp OPMA00071

机译：JBIR-150，来自海洋衍生的链霉菌SP OPMA00071的新型20元聚烯Macrolactam

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

During the course of constructing a natural product library for drug screening consisting of microbial culture extracts originated from marine samples, we evaluated natural product components profiles via UPLC TOF-MS and routine biological tests for cytotoxic and antibiotic activities for all of the culture extract samples. By combination of chemical screening and biological activities, we succeeded in discovering a 20-membered macrolactam antibiotic subsequently designated JBIR-150 (1) from a marine-derived actinomycete identified as Streptomyces sp. that was isolated from an Okinawan marine sediment. The chemical structure of 1 was determined by interpreting NMR spectroscopic and mass spectrometric data. Compound 1 exhibited moderate cytotoxicity against MESO-1 and Jurkat cells.

机译：在构建由源自船舶样品的微生物培养基提取物组成的药物筛选的天然产物文库期间，我们通过UPLC TOF-MS评估了天然产物组分谱和用于所有培养提取物样品的细胞毒性和抗生素活性的常规生物试验。通过化学筛选和生物活性的组合，我们成功地发现了20元的MacroAlam抗生素随后指定了来自鉴定为streptomyces sp的海洋衍生的放大菌网的JBIR-150（1）。从冲绳海洋沉积物中孤立。通过解释NMR光谱和质谱数据来确定1的化学结构。化合物1对Meso-1和Jurkat细胞进行中度细胞毒性。

著录项

来源
《The Journal of Antibiotics: An International Journal》 |2018年第3期|共3页
作者
Kawahara Teppei; Fujiwara Takeshi; Kagaya Noritaka; Shin-ya Kazuo;
展开▼
作者单位

JBIC Koto Ku 2-4-7 Aomi Tokyo 1350064 Japan;

OP Bio Factory Co Ltd Okinawa Life Sci Res Ctr 107 5-8 Suzaiki Okinawa Okinawa 9042234 Japan;

JBIC Koto Ku 2-4-7 Aomi Tokyo 1350064 Japan;

Natl Inst Adv Ind Sci &

Technol Koto Ku 2-4-7 Aomi Tokyo 1350064 Japan;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词

相似文献

外文文献
中文文献
专利

1. JBIR-150, a novel 20-membered polyene macrolactam from marine-derived Streptomyces sp OPMA00071 [J] . Kawahara Teppei, Fujiwara Takeshi, Kagaya Noritaka, The Journal of Antibiotics: An International Journal . 2018,第3期

机译：JBIR-150，来自海洋衍生的链霉菌SP OPMA00071的新型20元聚烯Macrolactam
2. New polycyclic tetramate macrolactams from marine-derived Streptomyces sp SCSIO 40060 [J] . Zhang Wenjun, Zhang Guangtao, Zhang Liping, Tetrahedron . 2018,第47期

机译：来自海洋衍生的链霉菌SP SCSIO 40060的新多环四酯酰胺 - 40060
3. Heronamides A-C, new polyketide macrolactams from an Australian marine-derived Streptomyces sp. A biosynthetic case for synchronized tandem electrocyclization [J] . Ritesh Raju, Andrew M. Piggott, Melissa M. Conte, Organic & biomolecular chemistry . 2010,第20期

机译：Heronamides A-C，来自澳大利亚海洋来源的链霉菌属的新型聚酮大内酰胺。同步串联电环化的生物合成案例
4. Study of Humic Acid and Multiantagonis of Streptomyces Sp, Trichoderma Sp Application Techniques for Horticulture Plant on Marginal Soil [C] . Penta Suryaminarsih, Wiwik Sri Harijani, Wanti Mindari, International Conference on Science and Technology . 2018

机译：植物酸及植物植物植物酸性酸和多目标研究边缘土园林园艺植物SP应用技术
5. Studies on biocontrol of Fusarium wilt of Cajanus cajan b Paenibacillus sp. D1 and Streptomyces sp. A6 [D] . Singh, Anil Kumar. 2010

机译：Cajanus cajan b Paenibacillus sp。枯萎病的生物防治研究。 D1和链霉菌sp。 A6
6. Genome Mining of Marine-Derived Streptomyces sp. SCSIO 40010 Leads to Cytotoxic New Polycyclic Tetramate Macrolactams [O] . Wei Liu, Wenjun Zhang, Hongbo Jin, 2019

机译：海洋衍生链霉菌sp。的基因组采矿。 SCSIO 40010导致细胞毒性的新型多环四酸酯大环内酰胺
7. Heronamides G–L, polyene macrolactams from Streptomyces niveus [O] . Nan Ding, Li Han, Yi Jiang, 2018

机译：Heronamides G-L，来自Streptomyces Niveus的Polyene Macro酰胺

JBIR-150, a novel 20-membered polyene macrolactam from marine-derived Streptomyces sp OPMA00071

摘要

著录项

相似文献

相关主题

期刊订阅