...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Antibiotics: An International Journal >Kanamycin and its derivative, arbekacin: significance and impact
【24h】

Kanamycin and its derivative, arbekacin: significance and impact

机译：卡那霉素及其衍生物，Arbekacin：意义和影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

On the occasion of the 60th anniversary of the discovery (1957) of kanamycin (KM), a series of research achievements on KM and its semisynthetic derivative Arbekacin (ABK) are outlined. KM was first used clinically in 1958 and was appreciated for its remarkable curing effect on various bacterial infections, especially tuberculosis. ABK is a KM derivative rationally semisynthesized to overcome KM resistance due to enzymatic phosphorylation and acetylation. Since its approval in 1990 as an anti-MRSA drug, ABK has been and still is effectively used in chemotherapy because MRSA rarely develops high ABK-resistance. Research that illuminated the unique features of ABK enabling it to resist the development of resistance by MRSA are also described.
机译：概述了Kanamycin（KANA）发现（1957年）的60周年，概述了一系列关于KM及其半合成衍生物Arbekacin（ABK）的研究成果。 KM首先在1958年临床使用，并赞赏其对各种细菌感染，尤其是结核病的显着养护作用。 ABK是km衍生物，合理半合成化以克服酶促磷酸化和乙酰化引起的km电阻。 自1990年批准以来作为抗MRSA药物，ABK一直仍然有效地用于化疗，因为MRSA很少发育高的ABK抗性。 还描述了照亮ABK独特特征的研究，使其能够抵抗MRSA的电阻的发展。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号