...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Antibiotics: An International Journal >Spiciferone analogs from an endophytic fungus Phoma betae collected from desert plants in West China
【24h】

Spiciferone analogs from an endophytic fungus Phoma betae collected from desert plants in West China

机译：来自西部沙漠植物中的内生真菌Phoma Betae的Spiciferone类似物

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Endophytic fungi from desert, arid, and grassland areas are an ecologically important but unique group with poor chemical investigation. During our ongoing study to mine bioactive secondary metabolites from unique fungal environments, a new shunt product spiciferone F (1) including two new analogs spiciferones G (2) and H (3) together with four known ones spiciferone A (4), spiciferol A (5), 6, and 7 were isolated from endophytic fungus Phoma betae inhabiting in plant Kalidium foliatum (Pall.) Moq from Ningxia Province of West China. The planar, relative, and absolute configurations of these new compounds were elucidated by nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, and electronic circular dichroism experiments. According to the shunt products, intermediates and analogs isolated from this endophytic fungus, the possible biosynthetic pathway of spiciferones was reconstructed. Compounds 1-7 were evaluated cytotoxic activities against three cancer cell lines HCT 116, HeLa, and MCF7, and only did 1 display strong biological effect against MCF7 with a half-maximal inhibitory concentration value at 7.73 +/- 0.11 mu M compared with the cis-platinum (14.32 +/- 1.01 mu M).
机译：来自沙漠，干旱和草原地区的内生真菌是一种生态上重要但独特的群体，化学调查差。在我们正在进行的矿井生物活性次生代谢物中，从独特的真菌环境中，新的分流产品Spififerone F（1）包括两个新的类似物Spififerones G（2）和H（3），与四个已知的Spififerone A（4），Spififerol A一起（5），6和7分离于来自宁夏西部的植物Kalidium foriatum（Pall。）Moq的内生真菌Phoma Betae中分离出来。通过核磁共振，高分辨率电喷雾电离质谱和电子圆形二色性实验阐明了这些新化合物的平面，相对和绝对构型。根据分流产品，中间体和来自这种内生真菌的中间体和类似物，重建了Spififerones的可能的生物合成途径。对化合物1-7评估针对三种癌细胞系HCT116，HELA和MCF7的细胞毒性活性，并且仅为7.73 +/- 0.11 mu m的半最大抑制浓度值显示出对MCF7的强烈生物学效应。比较CIS-铂（14.32 +/- 1.01 mu m）。

著录项

  • 来源
  • 作者

    Tan Xiang-Mei; Li Lu-Ying; Sun Li-Yan; Sun Bing-Da; Niu Shu-Bin; Wang Meng-Hua; Zhang Xiao-Yan; Sun Wen-Song; Zhang Gui-Shan; Deng Hui; Xing Xiao-Ke; Zou Zhong-Mei; Ding Gang;

  • 作者单位

    Chinese Acad Med Sci Inst Med Plant Dev Key Lab Bioact Subst &

    Resources Utilizat Chinese Minist;

    Chinese Acad Med Sci Inst Med Plant Dev Key Lab Bioact Subst &

    Resources Utilizat Chinese Minist;

    Taishan Med Univ Sch Pharmaceut Sci Tai An 271016 Shandong Peoples R China;

    Chinese Acad Sci Inst Microbiol Beijing 100090 Peoples R China;

    Beijing City Univ Sch Biol Med Beijing 450046 Peoples R China;

    Chinese Acad Med Sci Inst Med Plant Dev Key Lab Bioact Subst &

    Resources Utilizat Chinese Minist;

    Chinese Acad Med Sci Inst Med Plant Dev Key Lab Bioact Subst &

    Resources Utilizat Chinese Minist;

    Liaoning Res Inst Cash Crops Liaoyang 111000 Peoples R China;

    Chinese Acad Agr Sci Inst Agr Resources &

    Reg Planning Key Lab Microbial Resources Collect &

    Chinese Acad Agr Sci Inst Agr Resources &

    Reg Planning Key Lab Microbial Resources Collect &

    Chinese Acad Med Sci Inst Med Plant Dev Key Lab Bioact Subst &

    Resources Utilizat Chinese Minist;

    Chinese Acad Med Sci Inst Med Plant Dev Key Lab Bioact Subst &

    Resources Utilizat Chinese Minist;

    Chinese Acad Med Sci Inst Med Plant Dev Key Lab Bioact Subst &

    Resources Utilizat Chinese Minist;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号