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首页> 外文期刊>The Journal of Antibiotics: An International Journal >JBIR-44, a new bromotyrosine compound from a marine sponge Psammaplysilla purpurea.
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JBIR-44, a new bromotyrosine compound from a marine sponge Psammaplysilla purpurea.

机译：JBIR-44，来自海绵Psammaplysilla purpurea的新的溴旋霉素化合物。

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摘要

Marine sponges of the order Verongida are characterized by their ability to synthesize brominated tyrosine derivatives, many of which possess potent anti-microbial and cytotoxic activities.1 Purealin,2"4 Lipopurealin A-E,5,6 Purealidin A-S,6~n Psammaplysin A-B,12 Pur-puramine A-J,11,13 Aplysamines 2-514 and Macrocyclic peptides Bastadins15 isolated from Verongida have been previously reported as brominated tyrosine derivatives. The diverse modification of these biosynthetically related compounds occurs in both the side chain and aromatic ring of the brominated tyrosine precursors. It has been reported that many brominated tyrosine derivatives were isolated from Verongida, Psammaplysilla purpurea;1'2'5^10'13^15 therefore, P. purpurea is a potential resource for the chemical screening of novel compounds. We thus attempted to isolate new compounds from P. purpurea, and resulted in the isolation of a new compound designated as JBIR-44 (1) (Figure 1). In this paper, we report the isolation, structure elucidation and brief biological activity of 1.
机译：verongida订单的海洋海绵是它们合成溴化酪氨酸衍生物的能力，其中许多含有效率的抗微生物和细胞毒性活动.1 purieLin，2“4 Lipopurealin Ae，5,6嘌呤蛋白，6〜n psammaplysin ab，从诸如溴化酪氨酸衍生物之前，来自静脉内分离的Pur-puramine Aj，11,13 Aplysamines 2-514和致癌蛋白肽1514和大环肽Bastadins15已作为溴化酪氨酸衍生物。在溴化酪氨酸的侧链和芳香环中发生这些生物合成相关的化合物的多样性修饰据报道，据报道，许多溴化酪氨酸衍生物从静脉内染色，psammaplysilla purpurea分离; 1'2'5 ^ 10'13 ^ 15因此，p. purpurea是新型化合物的化学筛选的潜在资源。我们试图从p. pupurea中分离新化合物，并导致分离指定为JBIR-44（1）的新化合物（图1）。在本文中，我们报告了隔离，结构阐明和简短生物活性1。

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