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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Citrinamides, new potentiators of antifungal miconazole activity, produced by Penicillium sp. FKI-1938.
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Citrinamides, new potentiators of antifungal miconazole activity, produced by Penicillium sp. FKI-1938.

机译:柠檬蛋白酶,由青霉素SP产生的抗真菌咪康唑活性的新增强剂。 FKI-1938。

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摘要

Two new aromatic alkaloids, designated citrinamides A and B, were isolated from the culture broth of Penicillium sp. FKI-1938 by solvent extraction, silica gel column chromatography and HPLC. Their structures were elucidated by spectroscopic analysis, including NMR and amino acid analysis. Citrinamides A and B showed moderate potentiation of miconazole activity against Candida albicans.
机译:从Penicillium sp的培养肉汤中分离出两种新的芳族生物碱,指定的柠檬醋酸盐A和B. 通过溶剂萃取,硅胶柱色谱和HPLC FKI-1938。 它们的结构通过光谱分析阐明,包括NMR和氨基酸分析。 柠檬蛋白酰亚胺A和B显示咪康唑活性的中度增强对念珠菌蛋白糖苷蛋白酶。

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