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首页> 外文期刊>The Journal of Antibiotics: An International Journal >JBIR-31, a new teleocidin analog, produced by salt-requiring Streptomyces sp. NBRC 105896 isolated from a marine sponge.
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JBIR-31, a new teleocidin analog, produced by salt-requiring Streptomyces sp. NBRC 105896 isolated from a marine sponge.

机译：JBIR-31，一种新的左甲酰胺类似物，通过盐需要盐脲脲瘤性SP产生。 NBRC 105896从海绵中孤立。

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The marine environment has recently been described as a source of novel chemical diversity for drug discovery,1 as many bioactive substances are isolated from marine organisms including phytoplankton, algae, sponges, tunicates and mollusks.2,3 Our group has also reported the isolation of azaspiracid-24 and JBIR-445 from marine sponges. Microorganisms from marine habitats,6,7 especially actinobacteria, also constitute a promising untapped resource of novel compounds and are receiving special attention. Compared with higher organisms, microorganisms can be easily maintained under laboratory conditions ensuring a constant and inexpensive supply of their secondary metabolites. Moreover, compounds originally thought to be produced by a marine organism were later found to be produced by host-associated microorganisms.8 A significant body of work has emerged in the past 10 years on the isolation of actinobacteria from marine habitats and their screening has yielded several novel bioactive compounds.
机译：最近被描述为药物发现的新化学多样性的源泉，其中1种生物活性物质与海洋生物分离出，包括浮游植物，藻类，海绵，外形和软体动物.2,3我们的群体也报告了孤立来自海滨海绵的Azaspiracid-24和JBir-445。来自海洋栖息地的微生物，6,7尤其是抗菌菌，也构成了一个有前途的新型化合物资源，并受到特别关注。与较高的生物相比，可以在实验室条件下容易地保持微生物，确保其次级代谢物的恒定和廉价的供应。此外，最初认为由海洋生物产生的化合物后来被发现通过宿主相关的微生物产生.8在过去10年中出现了一系列重要的工作，患上海洋栖息地的抗菌杀菌剂分离出来几种新型生物活性化合物。

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