Tunicamycin: chemical synthesis and biosynthesis

Yamamoto Kazuki; Ichikawa Satoshi

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Tunicamycin: chemical synthesis and biosynthesis

机译：Tunicamycin：化学合成和生物合成

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Tunicamycins are nucleoside natural products and show antibacterial, antiviral and antitumor activities, which are attributed to their inhibition of enzymatic reactions between polyisoprenyl phosphate and UDP-GlcNAc or UDP-MurNAc-pentapeptide. Because of their various intriguing biological activities, tunicamycins have potential as therapeutic agents for infectious diseases or cancers. Structurally, tunicamycins have a unique structure composed of an undecodialdose skeleton, a lipid chain and a GlcNAc fragment linked by a 1,1-beta,alpha-trehalose-type glycosidic bond. In this mini review, we summarize the total chemical syntheses and biosynthetic studies of tunicamycins.

机译：唐尼霉素是核苷天然产物，表现出抗菌，抗病毒和抗肿瘤活性，其归因于它们抑制聚异戊二烯基磷酸酯和UDP-GLCNAC或UDP-Murnac-五肽之间的酶反应。由于它们各种有趣的生物活性，唐尼霉素具有作为传染病或癌症的治疗剂的潜力。在结构上，唐尼霉素具有由1,1-β - 海藻糖型糖苷键连接的未食指骨架，脂链和GlcNAc片段组成的独特结构。在这次迷你评论中，我们总结了唐氏霉素的总化学合成和生物合成研究。

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《The Journal of Antibiotics: An International Journal》 |2019年第12期|共10页
作者
Yamamoto Kazuki; Ichikawa Satoshi;
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作者单位

Hokkaido Univ Fac Pharmaceut Sci Kita Ku Kita 12 Nishi 6 Sapporo Hokkaido 0600812 Japan;

Hokkaido Univ Fac Pharmaceut Sci Kita Ku Kita 12 Nishi 6 Sapporo Hokkaido 0600812 Japan;

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正文语种 eng
中图分类药学;
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1. Tunicamycin: chemical synthesis and biosynthesis [J] . Yamamoto Kazuki, Ichikawa Satoshi The Journal of Antibiotics: An International Journal . 2019,第12期

机译：Tunicamycin：化学合成和生物合成
2. Biochemical pathways supporting beta-lactam biosynthesis in the springtail Folsomia candida Biochemical pathways supporting beta-lactam biosynthesis in the springtail Folsomia candida Biochemical pathways supporting beta-lactam biosynthesis in the springtail Folsomia candida [J] . Rhody Broekman, Janine Mari?n, Wouter Suring, Biology Open . 2016,第12期

机译：支持跳尾中的β-内酰胺生物合成的生化途径念珠菌生化途径支持跳尾中的β-内酰胺生物合成的生化途径念珠菌生化途径
3. Erythroglycan biosynthesis in K-562 cells. Inhibition of synthesis by tunicamycin and lack of attachment to the G-protein of vesicular-stomatitis virus [J] . J S Rush, R A Laine, S J Turco The biochemical journal . 1981,第1期

机译：K-562细胞中的赤藓糖苷生物合成。衣霉素对合成的抑制作用以及对水疱性口炎病毒的G蛋白缺乏附着力
4. Mimicking insect signaling: Artificial gland for biosynthesis and release of semiochemicals for communication [C] . Bula W. P., Dimov N. G., Munoz L., Micro Electro Mechanical Systems (MEMS), 2012 IEEE 25th International Conference on . 2012

机译：模仿昆虫信号：人工腺用于生物合成和释放化学信息素以进行交流
5. Towards renewable commodity chemicals: Biosynthesis of phloroglucinol and chemoenzymatic synthesis of caprolactam. [D] . Cox, Brad M. 2008

机译：迈向可再生商品化学品：间苯三酚的生物合成和己内酰胺的化学酶法合成。
6. Overexpression of a Gene That Encodes the First Enzyme in the Biosynthesis of Asparagine-Linked Glycans Makes Plants Resistant to Tunicamycin and Obviates the Tunicamycin-Induced Unfolded Protein Response [O] . Nozomu Koizumi, Tokuko Ujino, Hiroshi Sano, 1999

机译：天冬酰胺连接的聚糖的生物合成中编码第一个酶的基因的过表达使植物对衣霉素具有抗性并消除了衣霉素诱导的未折叠蛋白反应。
7. Overexpression of a Gene That Encodes the First Enzyme in the Biosynthesis of Asparagine-Linked Glycans Makes Plants Resistant to Tunicamycin and Obviates the Tunicamycin-Induced Unfolded Protein Response1 [O] . Koizumi, Nozomu, Ujino, Tokuko, Sano, Hiroshi, 1999

机译：天冬酰胺连接的聚糖的生物合成中编码第一个酶的基因的过表达使植物对衣霉素具有抗性，并消除了衣霉素诱导的未折叠蛋白反应1。

Tunicamycin: chemical synthesis and biosynthesis

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