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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Characterization of Severe Adverse Drug Reactions at a Free‐Standing Children's Hospital
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Characterization of Severe Adverse Drug Reactions at a Free‐Standing Children's Hospital

机译：在独立儿童医院对严重不良药物反应的特征

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Abstract We performed a retrospective chart review on severe adverse drug reactions (ADRs) detected by a pharmacovigilance program at a free‐standing pediatric hospital from January 2011 through September 2014. The pharmacist‐led program identifies ADRs using electronic medical record triggers. A systematic approach was used to classify ADR type and severity and assure accurate documentation. Data collection included demographics, implicated medication, type of ADR, Naranjo probability scale, ADR‐associated International Classification of Diseases, 9th Revision E codes, 30‐day mortality, and health care visit cost. One hundred sixty‐six severe pediatric ADRs were included, occurring in 163 unique patients. Severe ADRs were commonly associated with antimicrobials (48%), antineoplastics (10%), and antiepileptics (10%). The majority of ADRs were classified by the Naranjo probability scale as probable (59%). One hundred fifty‐four patients were admitted to the hospital, with a median length of stay of 3 days; 22 of these patients required admission to the pediatric intensive care unit for a median of 3 days. The median estimated health care cost associated with severe ADRs was $4055.52. No deaths occurred. Nearly 40% of severe ADRs would have gone unidentified using ADR‐associated International Classification of Diseases, 9th Revision E codes alone. The impact of pediatric ADRs on the health care system is underestimated. Strategies such as active pharmacovigilance programs enhance the identification, characterization, and documentation of these otherwise unrecognized ADRs.
机译：摘要我们对2011年1月至2014年1月的一家独立的儿科医院检测到的药物理解计划检测到的备注图表综述。药剂师LED计划使用电子医疗记录触发器识别ADR。系统方法用于分类ADR类型和严重性并确保准确的文档。数据收集包括人口统计数据，含义药物，ADR的类型，纳拉诺概率规模，ADR相关的疾病国际分类，第9次修订e代码，30天死亡率和医疗保健访问费用。包括一百六十六个严重的儿科ADR，在163名独特的患者中发生。严重的ADR通常与抗微生物（48％），抗肿瘤塑料（10％）和抗癫痫药（10％）有关。大多数ADRS由Naranjo概率规模分类为可能（59％）。一百五十四名患者被送往医院，中位长度为3天;这些患者中的22例需要进入儿科重症监护单位3天的中位数。与严重ADR相关的中位数估计的医疗保健成本为4055.52美元。没有发生死亡。近40％的严重ADRS将不明于使用ADR相关的国际疾病分类，第9次修订e代码。小儿ADR对医疗保健系统的影响被低估了。活跃药物检修计划等策略增强了这些违背的ADR的识别，表征和记录。

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