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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Analgesics and Sedatives in Critically Ill Newborns and Infants: The Impact on Long-Term Neurodevelopment
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Analgesics and Sedatives in Critically Ill Newborns and Infants: The Impact on Long-Term Neurodevelopment

机译：镇痛药和镇静剂在批评性新生儿和婴儿中：对长期神经发作的影响

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摘要

Inadequate pain and/or stress management in preterm- and term-born infants has been associated with increased morbidity and even mortality. However, exposure to analgosedatives during early infancy may also be one of the risk factors for subsequent neurodevelopmental impairment, at least in animal studies. Because infants admitted to neonatal or pediatric intensive care units may receive high amounts of these drugs for prolonged periods of time and the majority of these infants nowadays survive to discharge, this is of major concern. A balanced approach that incorporates the assessment and quantification of both wanted effects as well as unwanted side effects is therefore needed. In this article, the optimal dose determination of commonly used analgosedative drugs as well as their potential long-term effects on the developing human brain and neuropsychological functioning are reviewed.
机译：早产儿和术语出生婴儿的疼痛和/或压力管理不足与发病率甚至死亡率增加有关。 然而，在早期婴儿期间暴露于分析物也可能是随后的神经发育障碍的危险因素之一，至少在动物研究中。 由于患有新生儿或儿科重症监护单位的婴儿可能会在长时间的长时间接受大量这些药物，而今这些婴儿的大多数婴儿仍然存入出院，这是主要的关注点。 因此，因此需要一种融合了所需效果的评估和量化以及不需要的副作用的平衡方法。 在本文中，综述了常用的分析药物的最佳剂量测定，以及对显影人脑和神经心理学功能的潜在的长期影响。

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