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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Adverse Drug Reactions Across the Age Continuum: Epidemiology, Diagnostic Challenges, Prevention, and Treatments
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Adverse Drug Reactions Across the Age Continuum: Epidemiology, Diagnostic Challenges, Prevention, and Treatments

机译：跨年龄的不良药物反应连续性：流行病学，诊断挑战，预防和治疗

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摘要

Adverse drug reactions (ADRs) are common and important complications of drug therapy for children. The risk for ADRs changes over childhood, as do the nature and types of ADRs. Importantly, the risk and nature of ADRs in children are markedly different from those of adults, and adult data cannot be relied on to guide safe drug therapy in children. There are groups of children, notably those with complex and chronic diseases, who are at substantial risk for ADRs. The evaluation of an undesired effect during therapy is ideally accomplished by an organized approach that is a skill that clinicians who care for children-especially those children at high risk for ADRs must have. Additionally, clinicians as well as drug regulatory agencies and industry need to be both vigilant and astute as well as aware that ADRs in children are often different in nature and frequency from those in adults. The increasing use of pharmacogenomics to guide drug dosing and the increasing number of biological agents will provide new sets of challenges to clinicians over the next decade.
机译：不良药物反应（ADRS）是儿童药物治疗的常见和重要并发症。 ADRS对童年的变化的风险，以及ADR的性质和类型。重要的是，儿童ADR的风险和性质明显不同于成人的风险和性质，并且不能依赖成年数据来引导儿童安全药物治疗。有些孩子群体，特别是那些具有复杂和慢性病的人，他对ADRS具有很大的风险。治疗过程中不期望的效果的评价是通过有组织的方法实现的，这是一种技能，即照顾儿童的临床医生 - 特别是那些在ADR的高风险中的孩子必须拥有。此外，临床医生以及药物监管机构和行业都需要保持警惕和精明，并意识到儿童的ADR在大自然和频率上的自然和频率不同。越来越多的药物代理商在未来十年内向临床医生提供新的挑战。

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