Abrupt Symptom Improvements in Antidepressant Clinical Trials: Transient Placebo Effects or Therapeutic Reality?

Zilcha-Mano Sigal; Roose Steven P.; Brown Patrick J.; Rutherford Bret R.

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Abrupt Symptom Improvements in Antidepressant Clinical Trials: Transient Placebo Effects or Therapeutic Reality?

机译：抗抑郁药临床试验的突然症状改善：瞬态安慰剂效应或治疗现实？

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Background: According to prevailing models and classical reports, abrupt responses to antidepressant medication are not true drug responses but rather transient placebo effects. By contrast, recent reports suggest that early sudden improvements have a lasting effect and appear in most patients receiving medication. Clinical guidelines influenced by these contradictory findings are mixed and confusing.

机译：背景：根据普遍的模型和经典报告，突然对抗抑郁药物的反应不是真正的药物反应，而是瞬态安慰剂效应。相比之下，最近的报道表明，早期突然改善具有持久的效果，并且在接受药物的大多数患者中出现。受这些矛盾发现影响的临床指南都是混合和混乱的。

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来源
《The journal of clinical psychiatry》 |2019年第1期|共6页
作者
Zilcha-Mano Sigal; Roose Steven P.; Brown Patrick J.; Rutherford Bret R.;
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作者单位

Univ Haifa Dept Psychol IL-31905 Haifa Israel;

Columbia Univ Coll Phys &

Surg New York State Psychiat Inst New York NY 10032 USA;

Columbia Univ Coll Phys &

Surg New York State Psychiat Inst New York NY 10032 USA;

Columbia Univ Coll Phys &

Surg New York State Psychiat Inst New York NY 10032 USA;

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原文格式 PDF
正文语种 eng
中图分类精神病学;
关键词
Depression; Antidepressants; Geriatric Psychiatry; Research Methods and Statistics;

机译：抑郁症;抗抑郁药;老年精神病学;研究方法和统计;

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1. Abrupt Symptom Improvements in Antidepressant Clinical Trials: Transient Placebo Effects or Therapeutic Reality? [J] . Zilcha-Mano Sigal, Roose Steven P., Brown Patrick J., The journal of clinical psychiatry . 2019,第1期

机译：抗抑郁药临床试验的突然症状改善：瞬态安慰剂效应或治疗现实？
2. Antidepressant Controlled Trial For Negative Symptoms In Schizophrenia (ACTIONS): a double-blind, placebo-controlled, randomised clinical trial [J] . Barnes?T R, Leeson?V C, Paton?C, Health technology assessment: HTA . 2016,第29期

机译：精神分裂症阴性症状的抗抑郁药对照试验（ACTIONS）：一项双盲，安慰剂对照，随机临床试验
3. Direct effects of Tadalafil on lower urinary tract symptoms versus indirect effects mediated through erectile dysfunction symptom improvement: Integrated data analyses from 4 placebo controlled clinical studies [J] . BrockG.B., McVaryK.T., RoehrbornC.G., The Journal of Urology . 2014,第2期

机译：他达拉非对下尿路症状的直接作用与勃起功能障碍症状改善所介导的间接作用：4项安慰剂对照临床研究的综合数据分析
4. Effects of 650 nm-10.6 μm Combined Laser Acupuncture-Moxibustion on Knee Osteoarthritis:A Randomized,Double-blinded and Placebo-controlled Clinical Trial [C] . SHEN Xue-yong, DING Guang-hong, WU Fan, The 3rd Workshop on Scientific Approaches to Chinese Medicine(第三届中医科学研究方法研讨会)论文集 . 2008

机译：650 nm-10.6μm联合激光针灸对膝骨关节炎的影响：一项随机，双盲和安慰剂对照的临床试验
5. Trend analysis of changes in depressive symptom factors over time in clients receiving antidepressants or placebos. [D] . Follingstad, Joyce Eleane. 1993

机译：接受抗抑郁药或安慰剂的患者抑郁症状因素随时间变化的趋势分析。
6. Antidepressant Controlled Trial For Negative Symptoms In Schizophrenia (ACTIONS): a double-blind placebo-controlled randomised clinical trial. [O] . Thomas Re Barnes, Verity C Leeson, Carol Paton, -1

机译：精神分裂症阴性症状的抗抑郁药对照试验（ACTIONS）：一项双盲安慰剂对照随机临床试验。
7. Dose-Related Effects of Ketamine for Antidepressant-Resistant Symptoms of Posttraumatic Stress Disorder in Veterans and Active Duty Military: A Double-blind, Randomized, Placebo-Controlled Multi-Center Clinical Trial [O] . Chadi G. Abdallah, John D. Roache, Ralitza Gueorguieva, 2021

机译：氯胺酮对退伍军人抗抑郁症状抗抑郁症状的剂量相关的效果和现役军方的抗抑郁症状：双盲，随机，安慰剂控制的多中心临床试验

Abrupt Symptom Improvements in Antidepressant Clinical Trials: Transient Placebo Effects or Therapeutic Reality?

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