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首页> 外文期刊>The journal of clinical psychiatry >Relationship between current depressive symptoms and telomere length in a large, multiethnic sample
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Relationship between current depressive symptoms and telomere length in a large, multiethnic sample

机译：大，多民族样本中当前抑郁症状与端粒长度的关系

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Objective: Previous research has suggested that depressive symptoms may be associated with telomere length; however, findings have been mixed, and few studies have sought to generalize the results beyond samples of white individuals. The present study, conducted from August 2013 through August 2015, sought to examine the relationship between depressive symptoms and leukocyte telomere length in a large (N = 2,710), multiethnic sample (African American, white, Hispanic) and to determine if this relationship differed across ethnic/racial groups. Analyses were based on data taken from the Dallas Heart Study, a recent epidemiologic-style, population-based study of adults from Dallas County, Texas. Methods: Depressive symptoms were measured using the Quick Inventory of Depressive Symptomatology, and leukocyte telomere length was measured using a quantitative polymerase chain reaction technique. Analyses of the relationship between depressive symptoms and telomere length were conducted using multiple linear regression models. Results: Among the whole sample, there was no significant relationship between depressive symptoms and telomere length in either a basic (β = ?0.025, P= .190) or an adjusted (β = ?0.015, P= .443) model. However, among non-Hispanic white participants, depressive symptoms were significantly associated with telomere length in both basic (β = ?0.083, P= .014) and adjusted (β = ?0.066, P= .049) models. Conclusions: These findings suggest that ethnic/racial identification may be a factor in the relationship between depressive symptoms and telomere length and could impact the generalizability of previous research. ? Copyright 2017 Physicians Postgraduate Press, Inc.
机译：目的：以前的研究表明，抑郁症状可能与端粒长度有关;然而，发现已经混合，很少有研究旨在概括白人样本之外的结果。从2013年8月至2015年8月进行的本研究试图审查大（n = 2,710），多种族样本（非洲裔美国，白色，西班牙裔）和确定这种关系是否有不同的抑郁症状和白细胞端粒长度之间的关系跨越民族/种族群体。分析是基于达拉斯心脏研究的数据，德克萨斯州达拉斯县的达拉斯县成年人的最新流行病学风格。方法：使用快速抑郁症状抑郁症状测量抑郁症状，使用定量聚合酶链式反应技术测量白细胞端粒长度。使用多元线性回归模型进行抑郁症状与端粒长度之间的关系的分析。结果：在整个样本中，抑郁症状和端粒长度在碱性（β=Δ0.025，p = .190）或调整后（β= 0.015，P = .443）模型中没有显着的关系。然而，在非西班牙裔白人参与者中，抑郁症状与基本（β= 0.083，P = .014）中的端粒长度明显相关，并调整（β=Δ066，p = .049）模型。结论：这些研究结果表明，种族/种族鉴定可能是抑郁症状和端粒长度之间关系的一个因素，并且可能影响先前研究的普遍性。还版权所有2017 Physicians Postgraduate Fluss，Inc。

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