• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of clinical psychiatry >A critical review of selective serotonin reuptake inhibitor-associated bleeding: balancing the risk of treating hepatitis C-infected patients.
【24h】

A critical review of selective serotonin reuptake inhibitor-associated bleeding: balancing the risk of treating hepatitis C-infected patients.

机译：选择性血清素再摄取抑制剂相关出血的批判性综述：平衡治疗丙型肝炎患者的风险。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are increasingly being used to treat interferon-associated side effects in patients receiving hepatitis C virus (HCV) therapy. Because there is an increased risk of bleeding in HCV-infected patients who have developed cirrhosis and either portal hypertension or hepatic failure or both, we critically reviewed the literature on SSRI-associated bleeding. DATA SOURCES AND STUDY SELECTION: We performed a MEDLINE search of literature from 1966 to the present using hemorrhage, SSRI, and antidepressants as search terms and followed up on relevant citations. We reviewed 6 retrospective studies, 5 of which were case-control studies, and 18 case reports of bleeding in 37 people. Our review is supplemented with a case report of a possible connection between SSRI treatment and a fatal gastrointestinal bleed in an HCV-infected man. DATA SYNTHESIS: Bleeding events in 12/18 reports (67%) describing 19/24 people (79%) were closely associated with the use of SSRIs. CONCLUSION: Combining aspirin or nonsteroidal anti-inflammatory drugs with SSRIs for the treatment of interferon-associated neuropsychiatric side effects increases the risks of hemorrhage in patients with HCV who have developed cirrhosis and either portal hypertension or hepatic failure or both. We recommend that clinicians exercise caution when prescribing medications that can promote spontaneous bleeding to patients with multiple risk factors for internal hemorrhage.
机译：背景：选择性血清素再摄取抑制剂（SSRIS）越来越多地用于治疗接受丙型肝炎病毒（HCV）治疗的患者的干扰素相关的副作用。由于HCV感染患者出血的风险增加，因此已经开发了肝硬化和门静脉高血压或肝脏衰竭或两者，因此我们批评了SSRI相关出血的文献。数据来源和学习选择：我们从1966年对文学的Medline搜索到现在使用出血，SSRI和抗抑郁药作为搜索条件并跟进相关引用。我们审查了6项回顾性研究，其中5项是病例对照研究，18例案例报告有37人出血。我们的审查补充了SSRI治疗与HCV感染者在HCV感染者中可能的联系的案例报告。数据综合：12/18报告中的出血事件（67％）描述19/24人（79％）与使用SSRIS密切相关。结论：将阿司匹林或非甾体抗炎药与SSRIS治疗干扰素相关的神经精神副作用相结合增加了HCV患者出血的风险，患有肝硬化和门静脉高血压或肝功能衰竭或两者。我们建议临床医生在规定药物时谨慎，这些药物可以促进对内出血具有多种危险因素的患者的自发性出血。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号