Higher Baseline Proinflammatory Cytokines Mark Poor Antidepressant Response in Bipolar Disorder

Benedetti Francesco; Poletti Sara; Hoogenboezem Thomas A.; Locatelli Clara; de Wit Harm; Wijkhuijs Annemarie J. M.; Colombo Cristina; Drexhage Hemmo A.

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Higher Baseline Proinflammatory Cytokines Mark Poor Antidepressant Response in Bipolar Disorder

机译：较高的基线促炎细胞因子标记双相障碍的抗抑郁症应答

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Background: The clinical relevance of raised levels of circulating cytokines in bipolar disorder is still unclear. Cytokines influence neurotransmitters, neuroplasticity, and white matter integrity. An inconsistent literature suggests that higher cytokine levels could hamper antidepressant response. Total sleep deprivation (TSD) and light therapy (LT) prompt a rapid antidepressant response and can provide a model treatment to study predictors of response.

机译：背景：双相障碍循环细胞因子升高水平的临床相关性尚不清楚。细胞因子影响神经递质，神经塑性和白质完整性。不一致的文献表明，较高的细胞因子水平可能会阻碍抗抑郁症反应。总睡眠剥夺（TSD）和光疗法（LT）促使快速抗抑郁症反应，可以提供模型治疗，以研究反应的预测因子。

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来源
《The journal of clinical psychiatry》 |2017年第8期|共8页
作者
Benedetti Francesco; Poletti Sara; Hoogenboezem Thomas A.; Locatelli Clara; de Wit Harm; Wijkhuijs Annemarie J. M.; Colombo Cristina; Drexhage Hemmo A.;
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作者单位

Sci Inst Osped San Raffaele Div Neurosci Milan Italy;

Sci Inst Osped San Raffaele Div Neurosci Milan Italy;

Erasmus Univ Dept Immunol Med Ctr Rotterdam Netherlands;

Sci Inst Osped San Raffaele Div Neurosci Milan Italy;

Erasmus Univ Dept Immunol Med Ctr Rotterdam Netherlands;

Erasmus Univ Dept Immunol Med Ctr Rotterdam Netherlands;

Univ Vita Salute San Raffaele Sch Med Milan Italy;

Erasmus Univ Dept Immunol Med Ctr Rotterdam Netherlands;

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正文语种 eng
中图分类精神病学;
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2. Higher Baseline Proinflammatory Cytokines Mark Poor Antidepressant Response in Bipolar Disorder [J] . Benedetti Francesco, Poletti Sara, Hoogenboezem Thomas A., The journal of clinical psychiatry . 2017,第8期

机译：较高的基线促炎细胞因子标记双相障碍的抗抑郁症应答
3. Continuous circular cycling in bipolar disorders as a predictor of poor response to short-term antidepressant treatment [J] . Tundo A., Calabrese J. R., Proietti L., Bipolar disorders. . 2016,第Suppla1期

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6. Acute opioid effects on cortisol and cytokines in bipolar disorder [D] . Mascarenhas, Justine 2007

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Higher Baseline Proinflammatory Cytokines Mark Poor Antidepressant Response in Bipolar Disorder

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