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首页> 外文期刊>The Journal of dermatology >Cross‐sectional multicenter observational study of psoriatic arthritis in Japanese patients: Relationship between skin and joint symptoms and results of treatment with tumor necrosis factor‐α inhibitors
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Cross‐sectional multicenter observational study of psoriatic arthritis in Japanese patients: Relationship between skin and joint symptoms and results of treatment with tumor necrosis factor‐α inhibitors

机译：日本患者银屑病关节炎的横截面多中心观察研究：肿瘤坏死因子-α抑制剂皮肤与关节症状的关系及治疗结果

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Abstract Psoriatic arthritis (PsA) is an inflammatory arthritis with as yet unclear pathophysiology. This retrospective, multicenter, cross‐sectional study was conducted in 19 facilities in western Japan and aimed to identify patients’ characteristics and factors that affect the results of treatment with biologic agents. Of 2116 patients with psoriasis, 285 (13.5%) had PsA. Skin manifestations preceded joint manifestations in 69.8%, the onset was simultaneous in 17.2%, whereas PsA preceded skin manifestations in 2.5%. Peripheral arthritis was most common, occurring in 73.7%, compared with axial disease in 21.8%, enthesitis in 23.5% and dactylitis in 35.4%. Patients with severe skin manifestations were significantly younger at onset ( P ?=?0.02) and more frequently had axial disease ( P ??0.01). Biologic agents were used in 206 patients (72.3%), anti‐tumor necrosis factor ( TNF )‐α antibodies being prescribed first to 157 of them. Anti‐ TNF ‐α antibodies were continued by 105 participants and discontinued by 47, the remaining five patients being lost to follow up. Patients who discontinued anti‐ TNF ‐α antibodies were significantly older than those who continued (55 vs 51?years, P ?=?0.04) and significantly older at onset of joint manifestations (50 vs 44?years, P ?=?0.01). Multivariate analysis revealed that patients over 50?years significantly more frequently terminated anti‐ TNF ‐α antibodies ( P ??0.01). In conclusion, patients with PsA and severe skin manifestations have earlier onset and axial disease, which seriously impacts on quality of life. Anti‐ TNF ‐α antibodies were generally effective enough to continue but less so in patients aged over 50?years. Further detailed research is needed.
机译：摘要的银屑病关节炎（PSA）是一种炎症性关节炎，病理生理学尚不清楚。这种回顾性的多中心横断面研究是在日本西部的19个设施中进行的，旨在鉴定患者的特征和因素，这些特征和因素影响生物制剂治疗结果。 2116例牛皮癣患者，285例（13.5％）有PSA。皮肤表现先前的关节表现69.8％，发病同时为17.2％，而PSA前面的皮肤表现为2.5％。外周关节炎最常见，以73.7％发生，与轴向疾病相比，21.8％，诱滞炎在23.5％和三仙炎的35.4％。患有严重的皮肤表现患者在发病时显着较年轻（P？= 0.02），更频繁地具有轴向疾病（P？＆ 0.01）。生物制剂用于206名患者（72.3％），抗肿瘤坏死因子（TNF）-α抗体首先规定它们中的157例。抗TNF-α抗体持续105名参与者并停止47名，剩下的五名患者失去跟进。停止抗TNF-α抗体的患者比继续持续的人（55 v1？岁，P？= 0.04），并且在联合表现的发作明显较大（50 vs 44？年，P？= 0.01） 。多变量分析显示，患者超过50岁？多年的患者显着更频繁地终止的抗TNF-α抗体（P？＆Δ01）。总之，PSA和严重的皮肤表现患者早期发病和轴向疾病，这严重影响了生活质量。抗TNF-α抗体通常有效，以持续但在50多年的患者中较少。需要进一步详细的研究。

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