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首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >Carbon dioxide and retinopathy of prematurity in extremely low birth weight infants
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Carbon dioxide and retinopathy of prematurity in extremely low birth weight infants

机译：极低出生体重婴儿的二氧化碳和早产的视网膜病变

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Objective:To evaluate the relationship between partial pressure of carbon dioxide (PCO2) during the first 3 days of life and retinopathy of prematurity (ROP) in extremely low birthweight (ELBW) infants. Patients and methods:A retrospective evaluation of data on ELBW infants were collected over a period of 4 years. Data during the first 72 hours of life was divided into six, 12-hour epochs. The average highest and overall means of PCO2, PO2, FiO(2,)and glucose were calculated for each epoch. Logistic regression analysis was used to determine the association between PCO(2)and ROP after controlling for covariables. Results:A total of 78 neonates were included: birth weight (BW) (703 +/- 157 g) and gestational age (25 +/- 1.4 weeks). A total of 45 out of 78 had ROP: stage 1 (N = 8), stage 2 (N = 26), stage 3 (N = 14), and plus (N = 4). The overall mean PCO(2)correlated with ROP in the first 72 hours of life (R = 0.31,p = .0069). This correlation was significant in epochs 2 (p = .049), 4 (p = .008) and 6 (p = .038). The average of the highest PCO(2)also correlated with ROP in the first 72 hours of life (R = 0.38,p = .0007). This correlation was significant in epochs 2 (p = .0115), 4 (p = .0011), 5 (p = .028) and 6 (p = .037). The correlation between the stage of ROP and PCO(2)was significant after controlling for PO(2)and glucose concentrations. Other variables that correlated with ROP were the overall means of FiO(2)(R = 0.23,p = .04), PO2(R = 0.39,p = .0005) and glucose (R = 0.39,p = .0004) as well as the average highest concentrations of FiO(2)(R = 0.26,p = .025), PO2(R = 0.38,p = .0008) and glucose (R = 0.34,p = .007). Conclusion:After controlling for confounding variables, ROP correlated with the overall means and average highest PCO2. ROP also correlated with FiO(2), PO(2)and glucose concentrations. Further studies are needed to define the safe PCO(2)range and the effect of PCO(2)on the normal development of the retina.
机译：目的：评价在极低出生体重（ELBW）婴幼儿的生命前3天生命的前3天（ROP）的前3天内压力（PCO2）的关系。患者及方法：在4年内收集了Elbw婴儿数据的回顾性评估。寿命前72小时的数据分为六个，12小时的时期。为每个时代计算PCO2，PO2，FIO（2，）和葡萄糖的平均最高和总体方法。逻辑回归分析用于确定在控制协变者后PCO（2）和ROP之间的关联。结果：共有78个新生儿：出生体重（BW）（703 +/- 157克）和孕龄（25 +/- 1.4周）。总共45个具有rOP：阶段1（n = 8），第2阶段（n = 26），第3阶段（n = 14）和加（n = 4）。总体平均值PCO（2）在寿命的前72小时内与ROP相关（R = 0.31，P = .0069）。在时期2（p = .049），4（p = .008）和6（p = .038）中，这种相关性是显着的。最高PCO（2）的平均值也与寿命的前72小时内的ROP相关（r = 0.38，p = .0007）。在时期2（p = .0115），4（p = .0011），5（p = .028）和6（p = .037）中，这种相关性是显着的。在控制PO（2）和葡萄糖浓度后，ROP和PCO（2）阶段之间的相关性是显着的。与ROP相关的其他变量是FIO（2）（r = 0.23，p = .04）的总体方法，PO2（r = 0.39，p = .0005）和葡萄糖（r = 0.39，p = .0004）为以及平均最高浓度的FIO（2）（r = 0.26，p = .025），PO2（r = 0.38，p = .0008）和葡萄糖（r = 0.34，p = .007）。结论：控制混淆变量后，ROP与整体手段和平均最高PCO2相关。 ROP还与FIO（2），PO（2）和葡萄糖浓度相关。需要进一步的研究来确定PCO（2）范围和PCO（2）对视网膜正常发育的影响。

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