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首页> 外文期刊>The journal of maternal-fetal & neonatal medicine >The association between fetal fibronectin and spontaneous preterm birth in twin pregnancies with a shortened cervical length
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The association between fetal fibronectin and spontaneous preterm birth in twin pregnancies with a shortened cervical length

机译：颈部长度胎儿纤维凝集素与自发早产的关联

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Objective: To estimate the association between a positive fetal fibronectin (fFN) and spontaneous preterm birth (SPTB) in twin pregnancies with a shortened cervical length (CL). Study design: Retrospective cohort study of asymptomatic twin pregnancies managed by a single MFM practice from 2005 to 2016. We included all women with a shortened CL <=25mm at 22-28 weeks, and compared outcomes between women with a positive and negative fFN result. Results: One hundred fifty-five patients were included, 129 (83.2%) of whom had a negative fFN and 26 (16.8%) of whom had a positive fFN. Baseline characteristics were similar between groups, except for the CL at the time of diagnosis of short cervix (15 mm in the positive fFN group versus 20 mm in the negative fFN group, p = .002). The risk of SPTB <32 weeks was significantly higher in the positive fFN group (46.2 versus 12.6%, aOR 3.54, 95% Cl 1.26, 9.92) and the mean gestational age at delivery was significantly earlier (31.1 versus 35.2 weeks, p<.001). Conclusions: In asymptomatic women with twin pregnancies and a shortened CL, a positive fFN is significantly associated with SPTB and can modify the risk substantially. If performing a screening CL assessment in a twin pregnancy, fFN testing should be done concurrently.
机译：目的：估算颈部长度（CL）缩短颈部长度（CL）的双妊娠阳性胎儿纤连蛋白（FFN）和自发早产（SPTB）之间的关联。研究设计：从2005年至2016年开始审查队列队列的无症状双胞胎妊娠的研究。我们包括缩短CL <= 25mm的所有妇女在22-28周，妇女与阳性和负FFN结果的结果进行比较。结果：包括一百五十五名患者，其中129名（83.2％），其中29名（83.2％）有负FFN和26（16.8％），其中26名（16.8％）有正面FFN。基线特征在基团之间相似，除了在诊断短子宫颈时的Cl（在阳性FFN组中为15mm，在负FFN组中为20mm，p = .002）。 SPTB <32周的风险在阳性FFN组中显着高出显着较高（46.2与12.6％，AOR 3.54,95％Cl 1.26,9.92）和递送的平均孕龄较早（31.1与35.2周，P <。 001）。结论：在患有双胞胎怀孕的无症状妇女和缩短的CL中，阳性FFN与SPTB显着相关，可以大大修改风险。如果在双妊娠中进行筛选CL评估，则应同时进行FFN测试。

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